Tiagabine for the Treatment of Cocaine Dependence - 1
- Conditions
- Cocaine-Related Disorders
- Registration Number
- NCT00086255
- Lead Sponsor
- National Institute on Drug Abuse (NIDA)
- Brief Summary
The purpose of this study is to assess tiagabine for the treatment of cocaine dependence.
- Detailed Description
To assess the efficacy and safety of tiagabine in reducing cocaine use in subjects with cocaine dependence. It is hypothesized that tiagabine treatment, compared to placebo, will be associated with fewer days of cocaine use as assessed by self-report confirmed with urine assays for benzoylecgonine (BE). This is a double-blind, placebo-controlled, parallel-group design study, in which, after screening and a 2-week baseline assessment period, subjects will be equally randomly assigned to 1 of 2 treatment groups, tiagabine or matched placebo.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 140
Must be at least 18 years of age and be seeking treatment for cocaine dependence. Have the ability to understand, and having understood, provide written informed consent. If female, agree to use a method of birth control as indicated by the clinician. Please contact the participating site in your area for more information.
Please contact the participating site in your area for more information.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Drug use Cocaine use Addiction severity Clinical improvement
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (4)
Cincinnati VA Medical Center
🇺🇸Cincinnati, Ohio, United States
Boston University Medical Center
🇺🇸Boston, Massachusetts, United States
University of Texas Hlth Sci Ctr Houston
🇺🇸Houston, Texas, United States
Dayton VA Medical Center
🇺🇸Dayton, Ohio, United States