The Comparison of Analgesic Effect of Volatile Anesthetics Using Surgical Pleth Index
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 发起方
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- Remifentanil consumption (µg/kg/min)
研究概览
简要总结
The purpose of this clinical trial is to compare analgesic effect of sevoflurane and desflurane at equal minimum alveolar concentrations using surgical pleth index.
详细描述
Volatile anesthetics vary in their relative hypnotic potency. Recent studies demonstrated that equi-minimum alveolar concentration of various volatile anesthetic agents may produce different bispectral index values. However, the difference between analgesic effects of volatile anesthetics have not yet been investigated. The purpose of this clinical trial is to compare analgesic effect of sevoflurane and desflurane at equal minimum alveolar concentrations using surgical pleth index-guided remifentanil infusion.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 19 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients undergoing balanced general anesthesia using volatile anesthetics and remifentanil
- •patients with american society of anesthesiologist physical status I, II
- •patients aged 19-65 years
- •patients obtaining written informed consent
排除标准
- •patients with a history of any psychiatric or neurological disease
- •patients who had received any medication affecting the central nervous system
- •patients who had received medication affecting the sympathetic or parasympathetic nervous systems
- •patients undergoing tracheal intubation for airway management
- •pregnant women
研究组 & 干预措施
Sevoflurane
Anesthesia was maintained with sevoflurane.
干预措施: Sevoflurane (Drug)
Desflurane
Anesthesia was maintained with desflurane.
干预措施: Desflurane (Drug)
结局指标
主要结局
Remifentanil consumption (µg/kg/min)
时间窗: During the intraoperative period
次要结局
- Target effective site concentration of remifentanil (ng/ml)(After at least 10 min of stable surgical pleth index values)
研究者
Kyoungho Ryu
Clinical assistant professor
Kangbuk Samsung Hospital