The Different Analgesic Potency of Sevoflurane and Desflurane at Equi-minimum Alveolar Concentration
Trial Snapshot
- Phase
- Phase 3
- Status
- Completed
- Sponsor
- Enrollment
- 77
- Locations
- 1
- Primary Endpoint
- Analgesic potency of volatile anesthetics
Study Overview
Brief Summary
The aim of this clinical trial is to evaluate the difference of analgesic potency of sevoflurane and desflurane at equi-minimum alveolar concentration using a surgical pleth index.
Detailed Description
Volatile anesthetics vary in their relative hypnotic potencies. Recent studies demonstrated that equi-minimum alveolar concentration of various volatile anesthetics produced different EEG-derived indices such as bispectral index. However, there was no controlled study that demonstrates the difference of analgesic potency. The aim of this clinical trial is to evaluate the difference of analgesic potency of sevoflurane and desflurane at equi-minimum alveolar concentration using a surgical pleth index.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Prevention
- Masking
- Triple (Participant, Investigator, Outcomes Assessor)
Eligibility Criteria
- Ages
- 19 Years to 65 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •patients undergoing arthroscopic shoulder surgery
- •patients with american society of anesthesiologist physical status I, II
- •patients aged 19-65 years
- •patients obtaining written informed consent
Exclusion Criteria
- •patients with a history of any psychiatric or neurological disease
- •patients who had received any medication affecting the central nervous system
- •patients who had received medication affecting the sympathetic or parasympathetic nervous systems
- •patients who have not received interscalene approach brachial plexus block (refusal or failure)
- •pregnant women
Arms & Interventions
Sevoflurane
Anesthesia was maintained with sevoflurane.
Intervention: Sevoflurane (Drug)
Desflurane
Anesthesia was maintained with desflurane.
Intervention: Desflurane (Drug)
Outcomes
Primary Outcomes
Analgesic potency of volatile anesthetics
Time Frame: the first 60 min of maintaining a steady state 1 MAC of volatile agents
The analgesic potency was evaluated by surgical pleth index value
Secondary Outcomes
No secondary outcomes reported
Investigators
Kyoungho Ryu
Clinical assistant professor
Kangbuk Samsung Hospital