The Different Analgesic Potency of Sevoflurane and Desflurane at Equi-minimum Alveolar Concentration
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 发起方
- 入组人数
- 77
- 试验地点
- 1
- 主要终点
- Analgesic potency of volatile anesthetics
研究概览
简要总结
The aim of this clinical trial is to evaluate the difference of analgesic potency of sevoflurane and desflurane at equi-minimum alveolar concentration using a surgical pleth index.
详细描述
Volatile anesthetics vary in their relative hypnotic potencies. Recent studies demonstrated that equi-minimum alveolar concentration of various volatile anesthetics produced different EEG-derived indices such as bispectral index. However, there was no controlled study that demonstrates the difference of analgesic potency. The aim of this clinical trial is to evaluate the difference of analgesic potency of sevoflurane and desflurane at equi-minimum alveolar concentration using a surgical pleth index.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 19 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients undergoing arthroscopic shoulder surgery
- •patients with american society of anesthesiologist physical status I, II
- •patients aged 19-65 years
- •patients obtaining written informed consent
排除标准
- •patients with a history of any psychiatric or neurological disease
- •patients who had received any medication affecting the central nervous system
- •patients who had received medication affecting the sympathetic or parasympathetic nervous systems
- •patients who have not received interscalene approach brachial plexus block (refusal or failure)
- •pregnant women
研究组 & 干预措施
Sevoflurane
Anesthesia was maintained with sevoflurane.
干预措施: Sevoflurane (Drug)
Desflurane
Anesthesia was maintained with desflurane.
干预措施: Desflurane (Drug)
结局指标
主要结局
Analgesic potency of volatile anesthetics
时间窗: the first 60 min of maintaining a steady state 1 MAC of volatile agents
The analgesic potency was evaluated by surgical pleth index value
次要结局
未报告次要终点
研究者
Kyoungho Ryu
Clinical assistant professor
Kangbuk Samsung Hospital