The HEPALI Study

Recruiting

• Conditions: 1. Acute Lung Injury; <br />2. Acute Respiratory Distress Syndrome.

• Registration Number: NL-OMON28056

Brief Summary

/A

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 28

Inclusion Criteria

Inclusion criteria
All patients being intubated and mechanically ventilated in the ICU, who meet the International Consensus Criteria of ALI or ARDS:

Exclusion Criteria

1. Acute bleeding at any site;

2. Increased risk of bleeding:

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. TATc in BAL fluid;<br /> <br>2. PLI.<br>

Secondary Outcome Measures

Name	Time	Method
1. LIS;<br /><br>2. In blood: TF, TFPI activity, TFPI antigen, Factor VII/VIIa, protein C / activated protein C, prothrombin fragment 1.2, TATc, endogenous thrombin potential, fibrin monomers, soluble thrombomodulin, PAPc, PAI;<br /><br>3. In BAL fluid: TF, TFPI activity, TFPI antigen, Factor VII/VIIa, protein C / activated protein C, prothrombin fragment 1.2, TATc, endogenous thrombin potential, fibrin monomers, soluble thrombomodulin, PAPc, PAI;<br /><br>4. Occurrence and severity of bleeding events.<br>