Investigation of the effect of inhaled heparin in the treatment of patients with adult respiratory distress syndrome hospitalized in the intensive care unit

Phase 3

• Conditions: Acute respiratory distress syndrome.; Acute respiratory distress syndrome

• Registration Number: IRCT20190506043492N4
• Lead Sponsor: Ahvaz University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 13 July 2020

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Patients 18 to 60 years
Under mechanical ventilation for more than 48 hours
Respiratory index PAO2 / FIO2 =200 mmhg
Bilateral pulmonary infiltration in the chest x-ray
Lack of heart disease and previous lung disease
Positive end expiratory pressure or PEEP= ventilator 5 cmh2
No history of intracerebral hemorrhage in the past 12 months
No history of heparin-induced thrombocytopenia

Exclusion Criteria

Dissatisfaction to continue working on the study
Hypersensitivity to heparin
Uncontrolled bleeding or bleeding disorders
PTT and INR impaired
Patients receiving therapeutic doses of heparin, anaxaparin and warfarin

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Respiratory index: PAO2 / FIO2. Timepoint: 1 to 7 days after the intervention. Method of measurement: Ventilator.;Arterial blood gas parameters. Timepoint: 1 to 7 days after the intervention. Method of measurement: ABG test.;The amount of PEEP required for effective mechanical ventilation. Timepoint: 1 to 7 days after the intervention. Method of measurement: Ventilator.;The time required for mechanical ventilation. Timepoint: 1 to 7 days after the intervention. Method of measurement: The number of days it has been subjected to mechanical ventilationnumber.;Mortality rate is 48 hours and 7 days. Timepoint: 1 to 7 days after the intervention. Method of measurement: Mortality rate.;Respiratory parameters. Timepoint: 1 to 7 days after the intervention. Method of measurement: Lung capacity? Tidal Volume, Respiratory rate, Minute Ventilation, Paco2.