Evaluation of nebulized heparin efficacy in acute respiratory distress syndrome
Phase 3
Recruiting
- Conditions
- Acute respiratory distress syndrome.Acute respiratory distress syndrome
- Registration Number
- IRCT20230724058907N1
- Lead Sponsor
- Ahvaz University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 66
Inclusion Criteria
Children older than one month to 18 years old
The underlying disease of acute respiratory distress syndrome
Patients under mechanical ventilation for more than 48 hours with Pao2/Fio2<300
Patients who are expected to undergo invasive ventilation in the next 24 hours
In CXR, bilateral pulmonary infiltration can be seen (5cmH2O PEEP>)
Exclusion Criteria
History of allergy to heparin
Bleeding history in the last 3 months
History of any bleeding and coagulation disorders
History of cerebral hemorrhage in the last year
Uncontrolled active bleeding
Simultaneous use of antiplatelet, anticoagulant and thrombolytic drugs
Unwillingness to participate in the study
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Severity of acute respiratory distress syndrome. Timepoint: Time to enter the study or 0, 3, 5 and 7 days. Method of measurement: Pediatric acute respiratory distress syndrome criteria.
- Secondary Outcome Measures
Name Time Method