Macroscopic and microscopic changes of a locally advanced rectal tumour during radiotherapy: assessment using anatomical, functional and cinematic MRI.

Completed

• Conditions: Colorectal carcinoma; rectal cancer; 10017990; 10017991

• Registration Number: NL-OMON39583
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 15

Inclusion Criteria

- Rectal tumor < 15 cm anal verge
- Biopsy proven adenocarcinoma
- cT3-4 N0-2 M0: based on standard primary staging

Exclusion Criteria

- Patients who meet exclusion criteria for MRI at 3T
- Patients with inflammable bowel disease or diverticulitis
- Patients with history of pelvic surgery
- Patients with history of pelvic tumours

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Observational study to analyse rectal tumour regression and tumour movement<br /><br>during long course pre-operative RCT for LARC in order to develop a dose<br /><br>escalation strategy for rectal cancer. Besides this first endpoint it is also<br /><br>an explorative study to analyse the feasibility to apply anatomical and<br /><br>functional MRI during RCT in the evaluation of treatment response. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Not applicable.</p><br>