DRKS00034017招募中不适用
Development of an assay for endotyping nasal polyps via Interleukin-5 signaling and predicting a response to mepolizumab therapy
Klinik für Hals-Nasen-Ohrenheilkunde, Kopf- und Halschirurgie, St. Josefs-Hospital Hagen der Kath. Krankenhaus Hagen GmbH0 个研究点目标入组 60 人开始时间: 2024年4月11日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 60
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 Years 至 one（—）
- 性别
- All
入选标准
- •Recurrence of bilateral nasal polyps after one or more sinus surgeries despite current therapy with local and/or systemic cortisone therapy
- •- Nasal polyp score = 4 out of 8
- •- SNOT-22 (sino-nasal outcome test-22) = 35 points
- •- total symptom VAS (visual analog scale) = 5 out of 10 cm or 10 out of 20 cm
- •- Evidence of type 2 inflammation [13]: Tissue eosinophils = 10/hpf17 or blood eosinophils = 250u/l or total IgE = 100IU/ml
排除标准
- •- Infectious diseases such as HIV, hepatitis B and C
- •- Tumor diseases
- •- Autoimmune or non-type 2 inflammatory diseases
- •- Alcohol consumption in the last 4 weeks and positive rapid test kit result of ethyl glucuronide in urine
- •- Cigarette consumption in the last 4 weeks and positive rapid test kit result of cotinine in urine
- •- Use of illegal drugs in the last 12 weeks and positive rapid test kit result
- •- Therapy with other biologics in the last 12 weeks
- •- Acute infection or elevation of both leukocytes and C-reactive protein in the blood
- •- Use of systemic steroids in the last 4 weeks18
- •- pregnancy and breast-feeding
研究者
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