Comparison between dexamethasone and methylprednisolone in treatment of COVID-19
Phase 2
Recruiting
- Conditions
- COVID-19 disease.COVID-19U07.2, U07
- Registration Number
- IRCT20210223050466N1
- Lead Sponsor
- Shahre-kord University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 140
Inclusion Criteria
Patient with COVID-19
Under 80 y/o age
With positive RT-PCR test
With bilateral lung parenchyma infiltration
Blood oxygen saturation <93%
Did not take any medication or hospitalization for COVID-19
Taking any Corticosteroid
They have tendency to participate in this study
Exclusion Criteria
Patient leave hospital before discharge
Patient who expire in first 24 hour after admission
Patient with myocardial infarction during hospitalization
Patient with underlying disease who have contraindication of corticosteroid such as acute hepatitis, fungal infection
All patient who disagree to continue the study
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Blood oxygen saturation. Timepoint: In admission. Method of measurement: pulse oxymeter.;Duration of hospitalization. Timepoint: From admission to discharge. Method of measurement: Obsevation.;Duration between onset of symptom to start of corticosteroid. Timepoint: Before admission to start of drug. Method of measurement: Patient history.
- Secondary Outcome Measures
Name Time Method Mortality rate after 28 day. Timepoint: From admission to 28 day later. Method of measurement: Observation.;Number of oxygen dependency days. Timepoint: From admission to oxygen dependency time. Method of measurement: Observation.;Number of patient who need ICU admission. Timepoint: During hospitalization. Method of measurement: Obsevation.;Lab data. Timepoint: During admission , hospitalization and discharge. Method of measurement: Laboratory.