Genetic Analysis of Head and Neck Squamous Cell Carcinoma
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Head and Neck Cancer
- Sponsor
- Vanderbilt-Ingram Cancer Center
- Enrollment
- 74
- Primary Endpoint
- Viral DNAs related to demographics, tumor characteristics, and patient prognosis
- Status
- Completed
- Last Updated
- 13 years ago
Overview
Brief Summary
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
PURPOSE: This laboratory study is looking at DNA in tissue samples from patients with head and neck cancer.
Detailed Description
OBJECTIVES: * Assess common genetic mutations in tumor and germline DNA samples from patients with head and neck squamous cell carcinoma (HNSCC). * Search for viral DNAs and relate this information to demographics, tumor characteristics, and patient prognosis. * Search for novel viral sequences and cancer-associated gene mutations in young nonsmoking HNSCC patients and in other distinct head and neck cancers. * Determine tumor suppressor gene mutations in HNSCC patients and relate this information to gene expression data. * Validate gene expression information using independent techniques such as real-time PCR on expressed sequences and immunohistochemistry. OUTLINE: Genetic mutation analysis and gene expression studies are performed on tissue samples from patients with head and neck squamous cell carcinoma. Techniques used include real time-PCR and immunohistochemistry.
Investigators
Barbara Murphy, MD
Professor of Medicine, Medical Oncologist
Vanderbilt-Ingram Cancer Center
Eligibility Criteria
Inclusion Criteria
- •Patient with head and neck squamous cell carcinoma (HNSCC) enrolled in the Head and Neck Tissue Repository
- •Sufficient biological material collected to perform study tests
- •Historical material available from excess tissues at the Vanderbilt Pathology Department
Exclusion Criteria
- •Not specified
- •PRIOR CONCURRENT THERAPY:
- •Not specified
Outcomes
Primary Outcomes
Viral DNAs related to demographics, tumor characteristics, and patient prognosis
Time Frame: Upon collection of final patient data
Assess common genetic mutations in tumor and germline DNA samples
Time Frame: Upon collection of final patient data
Novel viral sequences and cancer-associated gene mutations in young nonsmoking patients with head and neck squamous cell carcinoma and in other distinct head and neck cancers
Time Frame: Upon collection of final patient data
Tumor suppressor gene mutations related to gene expression data
Time Frame: upon collection of final patient data
Validation of gene expression information using independent techniques such as real-time PCR on expressed sequences and immunohistochemistry
Time Frame: upon collection of final patient data