NCT00298714已完成4 期
Effect of Long-Term Administration of Oral Losartan on Hepatic Fibrogenesis and Gene Expression in Chronic Hepatitis C With Significant Liver Fibrosis.
适应症
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 20
- 主要终点
- Assessment of liver fibrogenesis by changes in gene expression of key mediators of liver fibrosis.
研究概览
简要总结
There is evidence on the beneficial effects of the administration of angiotensin II type 1 (AT1) receptors antagonists on liver fibrosis in hepatic stellate cells, experimental models of liver fibrosis in rodents and limited information in chronic hepatitis C with mild fibrosis.
The purpose of this study is to investigate the effect of long-term administration of oral Losartan, an AT1 receptor antagonist, on liver fibrogenesis in patients with chronic hepatitis C and fibrosis F2-F3 (METAVIR score).
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 35 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age between 35 and 65 years
- •chronic hepatitis C with intermediate fibrosis (F2-F3 in Metavir score).
- •non-responder or contraindication to antiviral therapy.
排除标准
- •any other cause of liver disease
- •HIV positive
- •alcohol consumption
- •arterial hypertension
- •creatinine > 1.5mg/dL
- •treatment with AT1 receptor antagonists or angiotensin converting enzyme inhibitors in the past 12 months.
- •antiviral therapy in the past 12 months
- •contraindications to oral losartan
结局指标
主要结局
Assessment of liver fibrogenesis by changes in gene expression of key mediators of liver fibrosis.
次要结局
未报告次要终点
研究者
相似试验
已完成
不适用
The Effect of Losartan on the Recoverability of Renal Function in Anuric and Oliguric Patients With Unilateral Obstructed KidneyLosartan Adverse ReactionUropathyUropathy ObstructiveNCT04278495Mansoura University96
已完成
3 期
Supplemental Benefit of Angiotensin Receptor Blocker in Hypertensive Patients With Stable Heart Failure Using OlmesartanChronic Heart FailureNCT00417222Tohoku University1,145
已完成
不适用
Attenuation of Cardiac Effects of Arteriovenous Fistula Creation With LosartanLeft Ventricular HypertrophyRenal FailureNCT00602004Melbourne Health52
已完成
4 期
ong-term Effects of an Angiotensin II Type 1 Receptor Blocker in Hypertensive Patients with Chronic Kidney Disease and Metabolic SyndromeHypertension Chronic kidney disease Metabolic syndromeJPRN-UMIN000010892Department of Cardiology Kinu Medical Association Hospital160
已完成
不适用
Effects of Losartan on Insulin Sensitivity and Secretion in Type 2 Diabetes and NephropathyType 2 DiabetesDiabetic NephropathyNCT00361023Shanghai Jiao Tong University School of Medicine25