Evaluation of a New MR Pulse Sequence to Quantify Liver Iron Concentration

Completed

• Conditions: Hemochromatosis

• Registration Number: NCT00587535
• Lead Sponsor: Mayo Clinic

Brief Summary

The purpose of this study is to determine if a new MR pulse sequence is accurate in determining how much iron is in the liver.

Detailed Description

Quantification of liver iron requires liver biopsy and histological assessment. New rapid MR techniques allow determination of liver relaxation times that can be altered with increasing iron deposition. The purpose of this study is to compare the results obtained with MRI to liver biopsy and iron quantification in patients undergoing liver biopsy in the setting of hemochromatosis.

Study Timeline

• Study Start: 2003-08
• Study First Submitted: 2007-12-21
• Study First Submitted QC: 2007-12-21
• Study First Posted: 2008-01-07
• Primary Completion: 2011-07
• Study Completion: 2011-07
• Status Verified: 2016-01
• Last Update Submitted: 2016-01-20
• Last Update Posted: 2016-01-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 18

Inclusion Criteria

• Undergoing liver biopsy for suspected or known hemochromatosis
• Undergoing liver biopsy for living-related liver donation evaluation

Exclusion Criteria

• Contraindication to MRI

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Accuracy of MR in quantifying liver iron	one time point

Trial Locations

Locations (1)

Mayo Clinic; 🇺🇸 Rochester, Minnesota, United States