Genicular Artery Embolisation (GAE) in Mild to Moderate Osteoarthritis: Correlation between Treatment Effect and Biochemical Biomarkers

Not Applicable

Recruiting

• Conditions: Knee osteoarthritis; Musculoskeletal - Osteoarthritis

• Registration Number: ACTRN12624001179527
• Lead Sponsor: I-MED Radiology Network

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2024-09-25
• Last Update Posted: 30 September 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

Participants deemed suitable for recruitment into the PRAETORIAN registry will be invited to decide if they would also like to participate in the sub-study. The inclusion and exclusion criteria for the PRAETORIAN registry are as follows, and there are no additional criteria for inclusion in this sub-study beyond those listed for the PRAETORIAN registry. Inclusion criteria for group A (patients with moderate-to-severe chronic pain following Total Knee Arthroplasty (TKA)):- Age 40 yrs or older who are willing and able to provide informed consent- Experiencing ongoing moderate to severe pain for at least 6 months after total knee arthroplasty- and having failed conservative medical treatment for at least 6 months (e.g. physiotherapy/anti-inflammatory/analgesia/masso-kinesiotherapy, etc.)Inclusion criteria for group B (patients with mild-to-severe Knee Osteoarthritis (KOA)):- Age 40 yrs or older who are willing and able to provide informed consent- Presence of mild to severe knee OA as stipulated by referring orthopedic surgeon- Presence of knee pain for at least 6 months, resistant to conservative treatments (e.g. physiotherapy, analgesia, exercise, weight loss, intra-articular injections, etc.)- Non-surgical candidates: ineligible/refused total knee arthroplasty (TKA)

Exclusion Criteria

The exclusion criteria are the same as those for the PRAETORIAN registry, with no additional exclusion criteria for this sub-study. The exclusion criteria are as follows: Exclusion criteria for group A (patients with moderate-to-severe chronic pain following Total Knee Arthroplasty (TKA)):- Rheumatoid, infectious arthritis, osteonecrosis, or advanced atherosclerosis- Malignancy- Renal impairment (eGFR <45)- A bleeding diathesis- Irreversible coagulopathy- Re-operation- Allergic to contrast mediaExclusion criteria for group B (patients with mild-to-severe Knee Osteoarthritis (KOA)):- Rheumatoid, infectious arthritis, osteonecrosis, or advanced atherosclerosis- Malignancy- Renal impairment (eGFR <45)- A bleeding diathesis- Irreversible coagulopathy- Allergic to contrast media

Study & Design

• Study Type: Observational
• Study Design: Not specified