Reference Values of Circulating Endothelial Progenitor Cells

• Conditions: Aortic Aneurysm

• Registration Number: NCT01918969
• Lead Sponsor: Hopital Jean Minjoz

Brief Summary

Circulating endothelial progenitor cells CD34+144+CD14- et CD34+VEGF-R2+CD14- have been shown to be inversely correlated to aortic aneurysm size. However reference values have not yet been determined. This study is aimed to determine reference values of CD34+144+CD14- et CD34+VEGF-R2+CD14- in healthy men and women blood donors.

Detailed Description

At the time of blood donation, 10mL of blood will be used to calculate the concentration of circulating endothelial progenitor cells CD34+144+CD14- et CD34+VEGF-R2+CD14- , and the ratio of circulating endothelial progenitor cells CD34+144+CD14- et CD34+VEGF-R2+CD14- / all circulating endothelial progenitor cells in order to determine reference values.

Study Timeline

• Status Verified: 2013-08
• Study First Submitted: 2013-08-06
• Study First Submitted QC: 2013-08-07
• Last Update Submitted: 2013-08-07
• Study First Posted: 2013-08-08
• Last Update Posted: 2013-08-08
• Study Start: 2013-10
• Primary Completion: 2014-01
• Study Completion: 2014-03

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

• Blood donors

Exclusion Criteria

• age over 65
• Arterial hypertension (treated or not)
• Vascular disease
• smoker or former smoker who stopped smoking for less than a year

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Concentration of circulating endothelial progenitor cells CD34+144+CD14- and CD34+VEGF-R2+CD14-	3 months

Secondary Outcome Measures

Name	Time	Method
Ratio of circulating endothelial progenitor cells CD34+144+CD14- et CD34+VEGF-R2+CD14- / all circulating endothelial progenitor cells	3 months

Trial Locations

Locations (1)

CHU Besançon; 🇫🇷 Besançon, France