NL-OMON43194撤回不适用
Arterial wall inflammation measured with 18F-FDG PET/CT in patients with familial hypercholesterolemia before and after treatment with a PCSK-9 inhibitor - FLASH
适应症
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 入组人数
- 52
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 64（—）
入选标准
- •patients with:
- •Aged 50 years or older
- •Familial hypercholesterolemia intermediate or severe genotype
- •Elevated LDL levels prior to start treatment
- •No previous cardiovascular events
- •No treatment with a PCSK9 inhibitor or willing to stop with the treatment for 6 weeks prior to baseline measurements
排除标准
- •1. Malignant diseases or any clinically significant medical condition that could interfere with the conduct of the study in the opinion of the investigator.
- •2. Chronic or recent (<1 month) infections and/or clinical signs of acute infection and/or CRP>10
- •3. Auto-immune diseases
- •4. Recent or chronic immunosuppressant or antibiotic usage
- •5. Type I or II diabetes mellitus
- •6. Standard contra-indications to 18F-FDG PET/CT based on physicians experience and current practices;Control group:
- •* A history of cardiovascular disease
- •* A known elevated risk factor for cardiovascular disease
- •* Use of any cardiovascular medication, including but not limited to lipid-lowering therapy, antihypertensive drugs, antidiabetic drugs, platelet aggregation inhibitors and anticoagulants
研究者
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