Tegafur-Uracil or Observation in Treating Patients With Stage II Colorectal Cancer That Has Been Completely Removed By Surgery
- Registration Number
- NCT00392899
- Lead Sponsor
- Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
- Brief Summary
RATIONALE: Drugs used in chemotherapy, such as tegafur-uracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving chemotherapy after surgery may kill any tumor cells that remain after surgery. Sometimes, after surgery, the tumor may not need more treatment until it progresses. In this case, observation may be sufficient. It is not yet known whether chemotherapy is more effective than observation in treating colorectal cancer.
PURPOSE: This randomized phase III trial is studying tegafur and uracil to see how well they work compared to observation in treating patients with stage II colorectal cancer that has been completely removed by surgery.
- Detailed Description
OBJECTIVES:
Primary
* Compare the efficacy of adjuvant tegafur-uracil vs observation only in patients with curatively resected stage II colorectal cancer.
Secondary
* Compare relapse-free and overall survival of patients treated with these regimens.
* Compare the occurrence of adverse events in patients treated with these regimens.
OUTLINE: This is a randomized, controlled study. Patients are randomized to 1 of 2 treatment arms.
* Arm I: Patients undergo observation.
* Arm II: Patients receive oral tegafur-uracil on days 1-5. Treatment repeats every 7 days for 1 year in the absence of disease progression or unacceptable toxicity.
After completion of study treatment, patients are followed periodically for 5 years.
PROJECTED ACCRUAL: A total of 2,000 patients will be accrued for this study.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 2025
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description UFT adjuvant therapy group UFT adjuvant chemotherapy UFT is given at a dose of 500-600 mg/day as tegafur in 2 divided doses after meals for 5 days, followed by a 2-day rest. This one-week cycle is repeated for one year. During protocol treatment, clinical findings and laboratory values are evaluated every month. After the completion of protocol treatment, patients are followed-up, according to the schedule defined in the study protocol, for 5 years until recurrence, other malignancy or death is confirmed.
- Primary Outcome Measures
Name Time Method Disease-free survival 9 years Disease-free survival is defined as the time from date of enrollement until date of recurrence, other malignancies or death from any cause, whichever comes first.
- Secondary Outcome Measures
Name Time Method Overall survival 9 years Overall survival is defined as time from date of enrollment until date of death from any cause.
Types and severities of adverse events 15 months Types and severities of adverse events from date of starting protocol treatment until 30 days after date of finishing the treatment are evaluated according to Japanese version of the National Cancer Institute Common Terminology Criteria for Adverse Events version 3.0 (CTCAE v3.0) by Translational Research Informatics Center.
Trial Locations
- Locations (272)
Otaru Ekisaikai Hospital
🇯🇵Asahikawa, Hokkaido, Japan
Fukuiken Saiseikai Hospital
🇯🇵Fukui-shi, Fukui, Japan
Nagoya Ekisaikai Hospital
🇯🇵Nagoya, Aichi, Japan
Saint Mary's Hospital
🇯🇵Kurume, Fukuoka, Japan
Nagoya Central Hospital
🇯🇵Nagoya, Aichi, Japan
West Medical Center Jouhoku Municipal Hospital
🇯🇵Nagoya, Aichi, Japan
Koseiren Kamo Hospital
🇯🇵Toyota, Aichi, Japan
Ban Buntane Houtokukai Hospital
🇯🇵Nagoya, Aichi, Japan
Nagoya Midori Municipal Hospital
🇯🇵Nagoya, Aichi, Japan
University of Fukui Hospital
🇯🇵Yoshida-gun, Fukui, Japan
Fukushima Medical University Hospital
🇯🇵Fukushima-shi, Fukushima, Japan
Juntendo Urayasu Hospital
🇯🇵Urayasu-shi, Chiba, Japan
Gunma Cancer Center
🇯🇵Otashi, Gunma, Japan
Aichi Cancer Center at Aichi Hospital
🇯🇵Okazaki, Aichi, Japan
Kitakyushu Municipal Medical Center
🇯🇵Kitakyushu, Fukuoka, Japan
Hashima City Hospital
🇯🇵Hashima, Gifu, Japan
National Hospital Organization Kure Medical Center
🇯🇵Kure, Hiroshima, Japan
Hyogo Cancer Center
🇯🇵Akashi, Hyogo, Japan
Shakai Hoken Kobe Central Hospital
🇯🇵Kobe, Hyogo, Japan
Hyogo College of Medicine
🇯🇵Nishinomiya, Hyogo, Japan
St. Marianna University Yokohama City Seibu Hospital
🇯🇵Yokohama, Kanagawa, Japan
Yokohama City University Medical Center
🇯🇵Yokohama, Kanagawa, Japan
Tsuchiura Kyodo General Hospital
🇯🇵Tsuchiura, Ibaraki, Japan
Kyoto First Red Cross Hospital
🇯🇵Higashiyama-ku, Kyoto, Japan
Kanazawa Medical University
🇯🇵Kahoku-gun, Ishikawa, Japan
Kanagawa Prefectural Ashigawa-kami Hospital
🇯🇵Ashigarakami-gun, Kanagawa, Japan
Nagano Municipal Hospital
🇯🇵Nagano-shi, Nagano, Japan
Aizawa Hospital
🇯🇵Matsumoto, Nagano, Japan
Oita University Hospital
🇯🇵Yufu-shi, Oita, Japan
Tokyo Metropolitan Fuchu Hospital
🇯🇵Fuchu, Tokyo, Japan
Niigata University Medical and Dental Hospital
🇯🇵Niigata-shi, Niigata, Japan
Hasuda Hospital
🇯🇵Hasuda, Saitama, Japan
Kansai Medical University Takii Hospital
🇯🇵Moriguchi, Osaka, Japan
Rinku General Medical Center
🇯🇵Izumisano, Osaka, Japan
Bell Land General Hospital
🇯🇵Sakai, Osaka, Japan
St. Luke's International Hospital
🇯🇵Chuo-ku, Tokyo, Japan
Izumiotsu Municipal Hospital
🇯🇵Izumiotsu, Osaka, Japan
Kurashiki Central Hospital
🇯🇵Kurashiki, Okayama, Japan
Osaka Rosai Hospital
🇯🇵Sakai-shi, Osaka, Japan
Nanpuh Hospital
🇯🇵Kagoshima, Japan
Oita Red Cross Hospital
🇯🇵Oita, Japan
Toyama Prefectural Central Hospital
🇯🇵Toyama-shi, Toyama, Japan
Ageo Central General Hospital
🇯🇵Ageo, Japan
Saiseikai Hiroshima Hospital
🇯🇵Aki-Gun, Japan
Kochi Health Sciences Center
🇯🇵Kochi, Japan
Kumamoto University Faculty of Medical and Pharmaceutical Sciences
🇯🇵Kumamoto, Japan
Chiba Cancer Center
🇯🇵Chiba, Japan
Hiroshima Prefectural Hospital
🇯🇵Hiroshima, Japan
Japanese Red Cross Kumamoto Hospital
🇯🇵Kumamoto, Japan
Metropolitan Bokutoh Hospital
🇯🇵Tokyo, Japan
Showa University Toyosu Hospital
🇯🇵Tokyo, Japan
Yamagata University Hospital
🇯🇵Yamagata, Japan
Saiseikai Yokohamashi Tobu Hospital
🇯🇵Yokohama, Japan
Hitachi Yokohama Hospital
🇯🇵Yokohama, Japan
Japanese Red Cross Society
🇯🇵Wakayama, Japan
Japan Labor Health and Welfare Organization Wakayama Rosai Hospital
🇯🇵Wakayama, Japan
Daisan Hospital
🇯🇵Komae, Tokyo, Japan
Tokyo Women's Medical University
🇯🇵Shinjyuku-ku, Tokyo, Japan
Showa General Hospital
🇯🇵Kodaira, Tokyo, Japan
Higashiyamato General Hospital
🇯🇵Higashiyamato, Tokyo, Japan
Nakano General Hospital
🇯🇵Nakano, Tokyo, Japan
Social Insurance Chuo General Hospital
🇯🇵Shinjuku-ku, Tokyo, Japan
Toyohashi Municipal Hospital
🇯🇵Toyohashi, Aichi, Japan
Teikyo University Chiba Medical Center
🇯🇵Ichihara, Chiba, Japan
Sumitomo Besshi Hospital
🇯🇵Niihama, Ehime, Japan
Social Insurance Tagawa Hospital
🇯🇵Tagawa, Fukuoka, Japan
Ogaki Municipal Hospital
🇯🇵Ogaki-shi, Gifu, Japan
Gunma University Graduate School of Medicine
🇯🇵Maebashi-shi, Gunma, Japan
Chugoku Central Hospital of the Mutual Aid Association of Public School Teachers
🇯🇵Fukuyama, Hiroshima, Japan
National Hospital Organization Fukuyama Medical Center
🇯🇵Fukuyama, Hiroshima, Japan
Asahikawa Medical College
🇯🇵Asahikawa, Hokkaido, Japan
Hakodate Goryoukaku Hospital
🇯🇵Hakodate, Hokkaido, Japan
Hirosaki University, School of Medicine
🇯🇵Otaru-shi, Hokkaido, Japan
Ako City Hospital
🇯🇵Akou, Hyogo, Japan
Hyogo Prefectural Amagasaki Hospital
🇯🇵Amagasaki, Hyogo, Japan
Himeji St. Mary's Hospital
🇯🇵Himeji, Hyogo, Japan
Kobe Medical Center
🇯🇵Kobe, Hyogo, Japan
Public Shiso General Hospital
🇯🇵Yamsakicho, Hyogo, Japan
Kinki Central Hospital
🇯🇵Itami, Hyogo, Japan
Takarazuka Municipal Hospital
🇯🇵Takarazuka, Hyogo, Japan
Kakogawa Municipal Hospital
🇯🇵Kakogawa, Hyogo, Japan
Nishi-Kobe Medical Center
🇯🇵Kobe, Hyogo, Japan
Kobe West City Hospital
🇯🇵Kobe, Hyogo, Japan
Higashi Takarazuka Satoh Hospital
🇯🇵Takarazukai, Hyogo, Japan
Iwate Medical University Hospital
🇯🇵Morioka, Iwate, Japan
Kanazawa University Hospital
🇯🇵Kanazawa, Ishikawa, Japan
Iwate Prefectural Central Hospital
🇯🇵Morioka, Iwate, Japan
Kagawa Rosai Hospital
🇯🇵Marugame, Kagawa, Japan
Kagawa University Hospital
🇯🇵Miki, Kagawa, Japan
Kagawa Prefectural Central Hospital
🇯🇵Takamatsu, Kagawa, Japan
Sagamihara National Hospital
🇯🇵Sagamihara, Kanagawa, Japan
Nippon Medical School Musashikosugi Hospital
🇯🇵Kawasaki, Kanagawa, Japan
Showa University Northern Yokohama Hospital
🇯🇵Yokohama-shi, Kanagawa, Japan
Showa University Fujigaoka Hospital
🇯🇵Yokohama, Kanagawa, Japan
Saiseikai Yokohama City Nanbu Hospital
🇯🇵Yokohama, Kanagawa, Japan
Yokohama City Hospital
🇯🇵Yokohama, Kanagawa, Japan
National Hospital Organization - Kumamotominami Hospital
🇯🇵Uki, Kumamoto, Japan
Kochi Medical School
🇯🇵Nankoku, Kochi, Japan
Japan Labor Health and Welfare Organization Kumamoto Rosai Hospital
🇯🇵Yashiro, Kumamoto, Japan
Yatsushiro Health Insurance General Hospital
🇯🇵Yatsushiro, Kumamoto, Japan
Kyoto Second Red Cross Hospital
🇯🇵Kanigyou-ku, Kyoto, Japan
Nantan General Hospital
🇯🇵Nantan, Kyoto, Japan
Mie University Graduate School of Medicine
🇯🇵Thu-shi, Mie, Japan
Miyagi Cancer Center
🇯🇵Natori-shi, Miyagi, Japan
Sendai Kousei Hospital
🇯🇵Sendai, Miyagi, Japan
Tohoku University Graduate School of Medicine
🇯🇵Sendai, Miyagi, Japan
Tohoku Rosai Hospital
🇯🇵Sendai, Miyagi, Japan
Sendai Medical Center
🇯🇵Sendai, Miyagi, Japan
Nagasaki University Hospital
🇯🇵Magasaki-shi, Nagasaki, Japan
Sasebo City General Hospital
🇯🇵Sasebo-shi, Nagasaki, Japan
Niigata Cancer Center Hospital
🇯🇵Niigata-shi, Niigata, Japan
Kawasaki Medical School
🇯🇵Kurashiki-shi, Okayama, Japan
Osaka City General Hospital
🇯🇵Osaka-shi, Osaka, Japan
Osaka Police Hospital
🇯🇵Osaka-shi, Osaka, Japan
Sakai Municipal Hospital
🇯🇵Sakai, Osaka, Japan
Suita Municipal Hospital
🇯🇵Suita-shi, Osaka, Japan
Osaka Medical College
🇯🇵Takatsuki, Osaka, Japan
Saiseikai Tondabayashi Hospital
🇯🇵Tondabayashi, Osaka, Japan
Fukaya Red Cross Hospital
🇯🇵Fukaya, Saitama, Japan
Saitama Medical University International Medical Center
🇯🇵Hidaka, Saitama, Japan
Kitasato Institute Medical Center Hospital
🇯🇵Kitamoto, Saitama, Japan
Omiya Medical Center ofJichi Medical School
🇯🇵Saitamaken, Saitama, Japan
National Defense Medical College
🇯🇵Tokorozawa, Saitama, Japan
Shiga University of Medical Science
🇯🇵Otsu-shi, Shiga, Japan
Otsu Municipal Hospital
🇯🇵Otsu, Shiga, Japan
Shimane Prefectural Central Hospital
🇯🇵Izumo-shi, Shimane, Japan
Fujieda Municipal General Hospital
🇯🇵Fujieda, Shizuoka, Japan
Hamamatsu University School of Medicine
🇯🇵Hamamatsu-shi, Shizuoka, Japan
Shizuoka Cancer Center
🇯🇵Sunto-gun, Shizuoka, Japan
Jichi Medical School
🇯🇵Shimotsuke-shi, Tochigi, Japan
Dokkyo University School of Medicine
🇯🇵Shimotsuga-gun, Tochigi, Japan
Social Insurance Kinan Hospital
🇯🇵Tanabe, Wakayama, Japan
Kyoto Prefectural University of Medicine
🇯🇵Kyoto, Japan
Konan Kosei Hospital
🇯🇵Konan, Japan
Southern TOHOKU research Institute for Neuroscience
🇯🇵Koriyama-city, Japan
Nishijin Hospital
🇯🇵Kyoto, Japan
National Hospital Organization - Kyoto Medical Center
🇯🇵Kyoto, Japan
Kyoto-Katsura Hospital
🇯🇵Kyoto, Japan
Muroran City General Hospital
🇯🇵Muroran, Japan
Nakatsu Municipal Hospital
🇯🇵Nakatsu, Japan
Saiseikai Nara Hospital
🇯🇵Nara, Japan
Nara Prefectual Nara Hospital
🇯🇵Nara, Japan
Oita Prefectural Hospital
🇯🇵Oita-shi, Japan
Saiseikai Niigata Daini Hospital
🇯🇵Niigata, Japan
Yodogawa Christian Hospital
🇯🇵Osaka, Japan
Osaka Red Cross Hospital
🇯🇵Osaka, Japan
Saitama Social Insurance Hospital
🇯🇵Saitama, Japan
Hakodate Municipal Hospital
🇯🇵Sendai, Japan
Miyagi Social Insurance Hospital
🇯🇵Sendai, Japan
Shizuoka City Hospital
🇯🇵Shizuoka, Japan
Shizuoka Municipal Shimizu Hospital
🇯🇵Shizuoka, Japan
Kawakita General Hospital
🇯🇵Suginami-ku, Japan
Tokushima University Hospital
🇯🇵Tokushima, Japan
Niigata Prefectural Tokamachi Hospital
🇯🇵Tokamachi, Japan
Mita Hospital at the International University of Health and Welfare
🇯🇵Tokyo, Japan
Tokyo Medical and Dental University
🇯🇵Tokyo, Japan
Nippon Medical School
🇯🇵Tokyo, Japan
Tokyo Metropolitan - Komagome Hospital
🇯🇵Tokyo, Japan
Tokyo Women's Medical University Medical Center East
🇯🇵Tokyo, Japan
NTT Kanto Medical Center
🇯🇵Tokyo, Japan
Toho University School of Medicine
🇯🇵Tokyo, Japan
Japanese Red Cross Medical Center
🇯🇵Tokyo, Japan
National Hospital Organization - Tokyo Medical Center
🇯🇵Tokyo, Japan
International Medical Center of Japan
🇯🇵Tokyo, Japan
Teikyo University School of Medicine
🇯🇵Tokyo, Japan
Jikei University School of Medicine Hospital
🇯🇵Tokyo, Japan
Takasago Kyoritsu Hospital
🇯🇵Tokyo, Japan
Toyama Red Cross Hospital
🇯🇵Toyama, Japan
Yamagata Prefectural Central Hospital
🇯🇵Yamagata, Japan
Yamagata Saisei Hospital
🇯🇵Yamagata, Japan
Yokohama City Minato Red Cross Hospital
🇯🇵Yokohama, Japan
Himeji Central Hospital
🇯🇵Himeji, Hyogo, Japan
Japanese Red Cross Nagoya First Hospital
🇯🇵Nagoya-shi, Aichi, Japan
Aichi Medical University
🇯🇵Aichi-gun, Aichi, Japan
Nagoya City University Hospital
🇯🇵Nagoya-shi, Aichi, Japan
Aichi Cancer Center
🇯🇵Nagoya, Aichi, Japan
Nagoya University School of Medicine
🇯🇵Nagoya, Aichi, Japan
Yamamoto Kumiai General Hospital
🇯🇵Noshiro, Akita, Japan
National Hospital Organization Toyohashi Medical Center
🇯🇵Toyohashi, Aichi, Japan
Hiraka General Hospital
🇯🇵Yokote, Akita, Japan
Nagoya University Hospital
🇯🇵Nagoya, Aichi, Japan
Asahi General Hospital
🇯🇵Asahi-machi, Chiba, Japan
Shikoku Cancer Center
🇯🇵Matsuyama, Ehime, Japan
Kyushu University Hospital
🇯🇵Fukuoka-shi, Fukuoka, Japan
Kurume University School of Medicine
🇯🇵Kurume, Fukuoka, Japan
University of Occupational and Environmental Health
🇯🇵Kitakyushu-shi, Fukuoka, Japan
Gifu Municipal Hospital
🇯🇵Gifu-shi, Gifu, Japan
Miyoshi Central Hospital
🇯🇵Miyoshi, Hiroshima, Japan
Kansai Rosai Hospital
🇯🇵Amagasaki, Hyogo, Japan
Kobe City General Hospital
🇯🇵Kobe-shi, Hyogo, Japan
Mito Saiseikai General Hospital
🇯🇵Mito, Ibaraki, Japan
Chigasaki Municipal Hospital
🇯🇵Chigasaki, Kanagawa, Japan
Fujisawa City Hospital
🇯🇵Fujisawa-shi, Kanagawa, Japan
Saint Marianna University School of Medicine
🇯🇵Kawasaki, Kanagawa, Japan
International Goodwill Hospital
🇯🇵Yokohama, Kanagawa, Japan
Yokosuka Kyosai Hospital
🇯🇵Yokosuka, Kanagawa, Japan
Kyoto University Hospital
🇯🇵Sakyo-ku, Kyoto, Japan
Iida Municipal Hospital
🇯🇵Iida, Nagano, Japan
Showa-Inan General Hospital
🇯🇵Komagane, Nagano, Japan
Hokushin Hospital
🇯🇵Nakano, Nagano, Japan
Japanese Red Cross Nagasaki Genbaku Hospital
🇯🇵Nagasaki-shi, Nagasaki, Japan
National Hospital Organization Nagasaki Medical Center
🇯🇵Omura, Nagasaki, Japan
Kenseikai Nara Coloproctology Center
🇯🇵Yamatotakada, Nara, Japan
Nara Medical University Cancer Center
🇯🇵Kashihara, Nara, Japan
Nagaoka Chuo General Hospital
🇯🇵Nagaoka, Niigata, Japan
Hoshigaoka Koseinenkin Hospital
🇯🇵Hirakata, Osaka, Japan
Minoh City Hospital
🇯🇵Mino, Osaka, Japan
Osaka Kosei Nenkin Hospital
🇯🇵Osaka-shi, Osaka, Japan
Osaka General Medical Center
🇯🇵Osaka-shi, Osaka, Japan
Kinki University School of Medicine
🇯🇵Osakasayama, Osaka, Japan
Saitama Medical School Hospital
🇯🇵Kawagoe-shi, Saitama, Japan
Ohtawara Red Cross Hospital
🇯🇵Ohtawawa, Tochigi, Japan
Juntendo University School of Medicine
🇯🇵Bunkyo-ku, Tokyo, Japan
Anan Kyoei Hospital
🇯🇵Anan, Tokushima, Japan
Tochigi Cancer Center
🇯🇵Utsunomiya, Tochigi, Japan
Yaizu Municipal Hospital
🇯🇵Yaizu, Shizuoka, Japan
Tokyo-Kita Social Insurance Hospital
🇯🇵Kita-ku, Tokyo, Japan
Kyorin University School of Medicine - Mitaka Campus
🇯🇵Mitaka, Tokyo, Japan
Tottori University - Faculty of Medicine
🇯🇵Yonago, Tottori, Japan
Koseiren Takaoka Hospital
🇯🇵Takaoka-shi, Toyama, Japan
Shingu Municipal Medical Center
🇯🇵Shingu, Wakayama, Japan
Wakayama Medical University
🇯🇵Wakayama-shi, Wakayama, Japan
Shimonoseki Kosei Hospital
🇯🇵Shimonoseki, Yamaguchi, Japan
National Hospital Organization - Kanmon Medical Center
🇯🇵Shimonoseki, Yamaguchi, Japan
Yamaguchi University Graduate School of Medicine
🇯🇵Ube, Yamaguchi, Japan
University of Yamanashi Faculty of Medicine
🇯🇵Chu-o-shi, Yamanashi, Japan
Akita Kumiai General Hospital
🇯🇵Akita, Japan
Aomori City Hospital
🇯🇵Aomori, Japan
Chiba University
🇯🇵Chiba, Japan
Kyoritsu General Hospital
🇯🇵Nagoya, Japan
Northern Fukushima Medical Center
🇯🇵Date, Japan
National Kyushu Cancer Center
🇯🇵Fukuoka, Japan
Matsunami General Hospital
🇯🇵Gifu, Japan
National Hospital Organization Kyushu Medical Center
🇯🇵Fukuoka, Japan
Chugoku Electric Power Hospital
🇯🇵Hiroshima-shi, Japan
Hiroshima University Hospital
🇯🇵Hiroshima, Japan
Hiroshima Red Cross Hospital and Atomic-bomb Survivors Hospital
🇯🇵Hiroshima, Japan
National Hospital Organization Mito Medical Center
🇯🇵Ibaraki, Japan
Hokkaido Chuo Rosai Hospital
🇯🇵Iwamizawa, Japan
Kitasato University School of Medicine
🇯🇵Kanagawa, Japan
Kobe Ekisaikai Hospital
🇯🇵Kobe, Japan
Osaka Minami Medical Center
🇯🇵Kawachinagano, Japan
Kiryu Kosei General Hospital
🇯🇵Kiryu, Japan
Saiseikai Matsusaka General Hospital
🇯🇵Matsusaka, Japan
Numazu City Hospital
🇯🇵Numazu, Shizuoka, Japan
Nakagami Hospital
🇯🇵Okinawa, Japan
Almeida Memorial Hospital
🇯🇵Oita, Japan
Okayama University Medical School
🇯🇵Okayama, Japan
Kitano Hospital
🇯🇵Osaka, Japan
Osaka Saiseikai Noe Hospital
🇯🇵Osaka, Japan
Otemae Hospital
🇯🇵Osaka, Japan
Osaka City Juso Hospital
🇯🇵Osaka, Japan
NTT West Osaka Hospital
🇯🇵Osaka, Japan
Higashi Sumiyoshi Morimoto Hospital
🇯🇵Osaka, Japan
Minamiosaka Hospital
🇯🇵Osaka, Japan
Nissay Hospital
🇯🇵Osaka, Japan
Saga Prefectural Hospital Koseikan
🇯🇵Saga, Japan
Sapporo-Kosei General Hospital
🇯🇵Sapporo-shi, Hokkaido, Japan
Akashi Municipal Hospital
🇯🇵Akashi, Hyogo, Japan
Kobe University Hospital
🇯🇵Kobe, Hyogo, Japan
Sano Hospital
🇯🇵Kobe, Hyogo, Japan
Sapporo Medical University
🇯🇵Sapporo, Hokkaido, Japan
Sapporo City General Hospital
🇯🇵Sapporo, Hokkaido, Japan
Social Insurance Yokohama Central Hospital
🇯🇵Yokohama, Kanagawa, Japan
Hokkaido University Graduate School of Medicine
🇯🇵Sapporo, Hokkaido, Japan
Kanagawa Cancer Center
🇯🇵Yokohama, Kanagawa, Japan
Japanese Red Cross Sendai Hospital
🇯🇵Sendai, Japan
Hyogo Prefectural Awaji Hospital
🇯🇵Sumoto, Hyogo, Japan
Kanto Rosai Hospital
🇯🇵Kawasaki, Kanagawa, Japan
National Hospital Organization - Nishisaitama-Chuo National Hospital
🇯🇵Tokorozawa, Saitama, Japan
Toho University Ohashi Hospital
🇯🇵Meguro-ku, Tokyo, Japan
Toranomon Hospital
🇯🇵Minato-ku, Tokyo, Japan