Impact of MRI of the fossa prostatica without endorectal coil in radiation therapy planning of local recurrent prostate cancer after radical prostatectomy.

• Conditions: C61; Malignant neoplasm of prostate

• Registration Number: DRKS00002960
• Lead Sponsor: niversitätsklinikum Freiburg

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2012-05-04
• Study Completion: 2013-12-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: Male
• Target Recruitment: 47

Inclusion Criteria

Patients with a history of prostate carcinoma and status after radical prostatavesikoektomy with biochemical (PSA) recurrence (definition of PSA recurrence: three consecutive rising PSA values ??above the nadir,> 6 months after surgery)
- Are not receiving anti-hormonal therapy
- Who have no impairment of renal function and no contraindications for the whole-body MRI
- Consent to participate in the study after detailed explanation of previous and written consent

Exclusion Criteria

- Clinical and imaging suspicion of lymph node metastases or distant metastases
- State of pelvic radiotherapy
- Known allergy to contrast agent gadolinium-chelates
- Renal (filtration rate <40 ml / min)
- After kidney or liver transplant
- Start an anti-hormonal therapy prior to study entry
- Contraindications to MR studies (pacemakers, metallic clips after magnetizable brain or heart surgery, cochlear implants, metallic foreign body in the eye, insulin pumps, etc.).
- Ferromagnetic intracorporeal debris
- Previous SM / AICD implantation

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Sensitivity and specificity of MRI for the detection of local recurrence in treatment planning

Secondary Outcome Measures

Name	Time	Method
PSA progression after salvage radiotherapy (Re-recurrence)