Outcome of High-risk Breast Lesions Diagnosed on Image-guided Core Needle Biopsy: Results From a Multicenter Retrospective Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 1,345
- 试验地点
- 1
- 主要终点
- upgrade rates related to histologic subtype, tissue sampling and other variables
研究概览
简要总结
In this multicenter study, the goal was to document the excisional biopsy or follow-up results of high risk lesions diagnosed on image guided CNB/VAB, and evaluate the clinical, imaging and histologic features for associated malignancy risk. The possibility of upgrade related to histologic subtype, tissue sampling and other variables was also evaluated.
详细描述
This is a retrospective multicentric study that include 1345 patients from 30 centers.
Patients who had a diagnosis of high risk lesions (HRL) on image guided core biopsy (tru-cut/vacuum biopsy) were reviewed in a 12 year period (between 2008 and 2020). The lesions included were ADH, LN (ALH/LCIS), papilloma (without or with atypia), RS, and FEA.
The patients who managed with an excisional biopsy or having at least 1 year follow-up documentation following the diagnosis of borderline lesion were included in the study.
Radiological findings, diameter of lesion (>15 vs <15 mm), needle biopsy type (14-16G vs 9-12G), sampling method and number of samplings (4 and >4 vs <4) were documented.
IBM SPSS Version 25.0 statistical package program was used for analysis.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Image guided needle biopsy diagnosis
- •Atypical ductal hyperplasia
- •Lobular neoplasia
- •Flat epithelial atypia
- •Papilloma
- •Radial scar
- •Diagnosed on image guided needle biopsy
排除标准
- •Fibroepithelial tumors
- •Mucocele like tumors
- •Diagnosed on surgical biopsy
结局指标
主要结局
upgrade rates related to histologic subtype, tissue sampling and other variables
时间窗: one year
the results from excisional biopsy or at least 1 year follow-up documentation
次要结局
未报告次要终点