Evaluation of the Effects of Tranexamic Acid and Chlorhexidine Gel on Alveolar Osteitis Incidence
试验速览
- 阶段
- 不适用
- 状态
- 进行中(未招募)
- 发起方
- 入组人数
- 98
- 试验地点
- 1
- 主要终点
- pain
研究概览
简要总结
This intervention is the treatment of alveolar osteitis (alveolitis) with different effects, which occurs due to the formation of clot after extraction, which is one of the most common intervals after tooth extraction.98 healthy patients with molar and premolar teeth with indication for extraction were taken to the Recep Tayyip Erdoğan University Faculty of Dentistry, Department of Oral and Maxillofacial Diseases and Surgery clinic between May 2024 and June 2024 (age: 38 sessions: 19). -62) 113 teeth (85 molar, 28 premolar teeth) were treated with Spongostan placed in the tooth socket after extraction, spongostan with Chlorhexidine gel and spongostan with tranexamic acid, randomly distributed. After extraction, alveolitis was observed and evaluated prospectively using spongostan, chlorhexidine gel and tranexamic acid in the dental sockets. The researcher checked the participants on the 3rd and 7th days after the tooth extraction. The researcher recorded the pain and edema levels by asking the participants between 0 and 10 using the Visual Analogue Scale (VAS). The researcher filled in the forms for the presence of halitosis, trismus and exposed bone socket on the 3rd and 7th days (YES-NO). Permanent analyzes of the study were created with the SPSS package program.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 65 Years(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy individuals between the ages of 18-65
- •Molar and premolar teeth with extraction indication
排除标准
- •Against drugs or substances to be used in surgery (articaine, tranexamic acid, chlorhexidine) have allergies,
- •Those who used antibiotics 30 days before the dental extraction,
- •Clinical and radiological examinations in the operation area 30 days before dental extraction and/or on the day of the procedure.
- •Any signs of pathology and infection (such as periapical pathology, pericoronitis),
- •Those who routinely use oral antiseptics,
- •Systemic fever, absence of growth such as lymphadenopathy (LAP),
- •Women are lactating or pregnant,
- •Using oral contraceptives,
- •Procedures that were not attended to control appointments (day 3-7) were not included.
研究组 & 干预措施
just absorbable gelatin
After tooth extraction, only saline irrigation was applied and a absorbable gelatin sponge was placed in the socket.
干预措施: Absorbable Gelatin (Drug)
absorbable gelatin with Chlorhexidine gel
After tooth extraction, after irrigation with saline, 2% chlorhexidine gel was absorbed into gelatin sponges and placed into the socket.
干预措施: Chlorhexidine (Drug)
absorbable gelatin with tranexamic acid
Tranexamic acid 50mg/ml for injection after saline irrigation after tooth extraction solution into gelatin sponges was applied to the socket after it was cured.
干预措施: Tranexamic acid (Drug)
结局指标
主要结局
pain
时间窗: 3.-7. days
scored on visual analog scale from 0 to 10
edema
时间窗: 3. day - 7. day
scored on visual analog scale from 0 to 10
trismus
时间窗: 3. day - 7. day
marked yes or no based on clinical examination
halitosis
时间窗: 3. day - 7. day
marked yes or no based on clinical examination
alveolar osteitis
时间窗: 3. day - 7. day
marked yes or no based on clinical examination
smoking habit
时间窗: operated day
marked yes or no based on anamnesis
age
时间窗: operated day
marked yes or no based on anamnesis
tooth type
时间窗: operated day
marked yes or no based on clinical examination
次要结局
未报告次要终点
研究者
Zeynep Gumrukcu
Associate Professor
Recep Tayyip Erdogan University
