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临床试验/NCT06435832
NCT06435832进行中(未招募)不适用

Evaluation of the Effects of Tranexamic Acid and Chlorhexidine Gel on Alveolar Osteitis Incidence

Recep Tayyip Erdogan University1 个研究点 分布在 1 个国家目标入组 98 人开始时间: 2024年5月16日最近更新:
适应症
干预措施
相关药物

试验速览

阶段
不适用
状态
进行中(未招募)
发起方
入组人数
98
试验地点
1
主要终点
pain

研究概览

简要总结

This intervention is the treatment of alveolar osteitis (alveolitis) with different effects, which occurs due to the formation of clot after extraction, which is one of the most common intervals after tooth extraction.98 healthy patients with molar and premolar teeth with indication for extraction were taken to the Recep Tayyip Erdoğan University Faculty of Dentistry, Department of Oral and Maxillofacial Diseases and Surgery clinic between May 2024 and June 2024 (age: 38 sessions: 19). -62) 113 teeth (85 molar, 28 premolar teeth) were treated with Spongostan placed in the tooth socket after extraction, spongostan with Chlorhexidine gel and spongostan with tranexamic acid, randomly distributed. After extraction, alveolitis was observed and evaluated prospectively using spongostan, chlorhexidine gel and tranexamic acid in the dental sockets. The researcher checked the participants on the 3rd and 7th days after the tooth extraction. The researcher recorded the pain and edema levels by asking the participants between 0 and 10 using the Visual Analogue Scale (VAS). The researcher filled in the forms for the presence of halitosis, trismus and exposed bone socket on the 3rd and 7th days (YES-NO). Permanent analyzes of the study were created with the SPSS package program.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Prevention
盲法
Double (Participant, Investigator)

入排标准

年龄范围
18 Years 至 65 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Healthy individuals between the ages of 18-65
  • Molar and premolar teeth with extraction indication

排除标准

  • Against drugs or substances to be used in surgery (articaine, tranexamic acid, chlorhexidine) have allergies,
  • Those who used antibiotics 30 days before the dental extraction,
  • Clinical and radiological examinations in the operation area 30 days before dental extraction and/or on the day of the procedure.
  • Any signs of pathology and infection (such as periapical pathology, pericoronitis),
  • Those who routinely use oral antiseptics,
  • Systemic fever, absence of growth such as lymphadenopathy (LAP),
  • Women are lactating or pregnant,
  • Using oral contraceptives,
  • Procedures that were not attended to control appointments (day 3-7) were not included.

研究组 & 干预措施

just absorbable gelatin

Active Comparator

After tooth extraction, only saline irrigation was applied and a absorbable gelatin sponge was placed in the socket.

干预措施: Absorbable Gelatin (Drug)

absorbable gelatin with Chlorhexidine gel

Active Comparator

After tooth extraction, after irrigation with saline, 2% chlorhexidine gel was absorbed into gelatin sponges and placed into the socket.

干预措施: Chlorhexidine (Drug)

absorbable gelatin with tranexamic acid

Active Comparator

Tranexamic acid 50mg/ml for injection after saline irrigation after tooth extraction solution into gelatin sponges was applied to the socket after it was cured.

干预措施: Tranexamic acid (Drug)

结局指标

主要结局

pain

时间窗: 3.-7. days

scored on visual analog scale from 0 to 10

edema

时间窗: 3. day - 7. day

scored on visual analog scale from 0 to 10

trismus

时间窗: 3. day - 7. day

marked yes or no based on clinical examination

halitosis

时间窗: 3. day - 7. day

marked yes or no based on clinical examination

alveolar osteitis

时间窗: 3. day - 7. day

marked yes or no based on clinical examination

smoking habit

时间窗: operated day

marked yes or no based on anamnesis

age

时间窗: operated day

marked yes or no based on anamnesis

tooth type

时间窗: operated day

marked yes or no based on clinical examination

次要结局

未报告次要终点

研究者

发起方
Recep Tayyip Erdogan University
申办方类型
Other
责任方
Principal Investigator
主要研究者

Zeynep Gumrukcu

Associate Professor

Recep Tayyip Erdogan University

研究点 (1)

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