Speckle tracking echocardiography in growth restricted fetuses.

Conditions: Fetal growth restriction
function of the heart
10016849

Registration Number: NL-OMON51474

Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 72

Inclusion Criteria

- An imminent iatrogenic preterm birth (between 24 and 34 weeks* gestation) of
a growth restricted fetus, receiving antenatal steroids in the context of
standard care to promote fetal lung maturation. Fetal growth restriction is
defined as an abdominal circumference or estimated fetal weight <10th
percentile with Doppler evidence of placental dysfunction;

- An imminent preterm birth (between 24 and 34 weeks* gestation) of an
appropriate for gestational age fetus, receiving antenatal steroids in the
context of standard care to promote fetal lung maturation. Appropriate for
gestational age is defined as an abdominal circumference or estimated fetal
weight >=10th percentile and no abnormal Doppler findings.

Exclusion Criteria

- Age <18 years;
- Fetal aneuploidy;
- Cardiac congenital anomalies in the fetus;
- Suspected or proven congenital infections;
- Administration of the first dose antenatal steroids >8 hours ago before the
first (baseline) ultrasound;
- Pregnant patients who are unable to reasonably assess their interests in
participating in the study.

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Left ventricle longitudinal strain rate at baseline and after administration of<br /><br>antenatal steroids in growth restricted fetuses compared with appropriate for<br /><br>gestational age fetuses.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Other speckle tracking- and conventional hemodynamical Dopplerparameters at<br /><br>baseline and after administration of antenatal steroids in growth restricted<br /><br>fetuses compared with appropriate for gestational age fetuses. These parameters<br /><br>include:<br /><br>- Measurements on global-, transverse- and basaleapical longitudinal<br /><br>contractility;<br /><br>- Systolic-, diastolic- and global function parameters: mitral- and tricuspid<br /><br>annular plane systolic excursion, peak early- and late transvalvular filling<br /><br>velocities and left and right myocardial performance index.<br /><br>- Morphometric parameters (left and right sphericity index);<br /><br>- Pulsatility index (PI) in the uterine arteries, umbilical artery, middle<br /><br>cerebral artery and ductus venosus. </p><br>