Effects of a High Intensity Resistance Training in Muscular Strength, Agility, and Body Composition of Anorexia Nervosa Restricting Type Patients

Not Applicable

Completed

• Conditions: Anorexia Nervosa Restricting Type
• Interventions: Behavioral: High-Intensity Resistance training

• Registration Number: NCT01906320
• Lead Sponsor: Universidad Europea de Madrid

Brief Summary

The aim is to test the hypothesis that high-resistance training for 8 weeks, following the recommendations for healthy adolescents, is capable of eliciting increases in muscle strength, agility, skeletal muscle mass, and functional capacity without losing weight, body mass index (BMI) or fat mass in anorexia nervosa restricting type patients. Further, we hypothesize that the effects produced by the high-resistance training program will be maintained 4 weeks following the completion of the training program.

Detailed Description

Not available

Study Timeline

• Study Start: 2009-01
• Primary Completion: 2012-06
• Study Completion: 2013-06
• Study First Submitted: 2013-07-17
• Study First Submitted QC: 2013-07-19
• Study First Posted: 2013-07-24
• Status Verified: 2020-12
• Last Update Submitted: 2020-12-28
• Last Update Posted: 2020-12-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 44

Inclusion Criteria

• diagnosed with anorexia nervosa restricting type
• age ≤16 years
• receiving psychological therapy 3 days/week, and daily life tracing (including diet)
• BMI >14.0 kg/m2

Exclusion Criteria

• being excessive exercisers (6 hours per week moderate to vigorous physical activity [1952 counts/min] upon admission)
• not being able to perform physical activity.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Training group	High-Intensity Resistance training	-

Primary Outcome Measures

Name	Time	Method
Changes in Body Composition - Anthropometry	3 times (week 0, week 8, week 12)	Body composition was obtained by collecting weight (kg) and height (m), and BMI was calculated as kg/m2. To obtain the % Fat Mass Heyward (2004) equation (specific for anorexia nervosa patients) was used. The skeletal muscle mass (SMM) was calculated using Poortmans (2005) equation. Fat Free Mass, and Fat mass where calculated based on Heyward and Poortmas equations.; Skinfolds, diameters and perimeters where measured following the International Society for the advancement of the Kinanthropometry (ISAK) guidelines.
Functional Capacity	3 times (week 0, week 8, week 12)	Functional capacity was assessed by a graded exercise test on a treadmill in conjunction with an ECG response, and under similar environmental conditions. Treadmill speed began at 3.0 km/h with a grade of 5.0%; both were increased by 0.3 km/h and 0.5% respectively every 30s. The test was terminated upon volitional fatigue of the patient or when they showed loss of ability to maintain the required workload.VO2peak was determined as the higher value obtained after a period of 20s. Ventilatory Threshold (VT) was determined using the O2 equivalent (VE∙VO2-1) and O2 end-tidal pressure (PetO2) without increases in the CO2 equivalent (VE∙VCO2-1).
Changes in Muscular Strength	3 times (week 0, week 8, week 12)	Muscular strength was assessed in the upper and lower body following a standardized strength testing protocol in the same resistance weight machines used in training sessions. The weightlifting training machines that were specifically built for the body size of children and adolescents (Strive Inc, PA, US) were used to carry out the 6RM (maximum repetitions) measured in Kilograms (kg). The lower body strength was assessed with seated leg-press, and upper body strength was assessed with seated bench press and seated lateral row
Changes in Agility	3 times (week 0, week 8, week 12)	To measure agility, we used the Time Up and Go (TUG) 3m and 10 m tests, and the Timed Up and Down Stairs (TUDS). These tests are reliable and validated for healthy children and adolescents, and used with other chronic pathologies such as cancer.

Secondary Outcome Measures

Name	Time	Method
Changes in perceived health-related QoL	2 times (week 0, week 8)	Patients were requested to fill in the SF-36 questionnaire to assess their perceptions in physical and mental health-related QoL
Changes in Spontaneous Physical Activity habits - Accelerometry	2 times (week 0, week 8)	Patients were required to maintain their normal physical activity while they were using an uni-axial accelerometer (Actigraph MTI, GT1M model, Manufacturing Technology Inc., Fort Walton Beach, FL, USA). At least 7 days were recorded (Monday-Sunday) with a minimum of 10-hour registration per day was set as an inclusion criterion. The time sampling interval (epoch) was set at 15 seconds. Average physical activity intensity was expressed as (sum of counts registered per epoch)/(Total Time Registered) (cpm). Time spent in light, moderate, vigorous, very vigorous and moderate to vigorous physical activity (MVPA) was presented as means per day depending on the metabolic equivalents (MET). Time spent in low intensity physical activity or sedentary time was the total time registered minus the total time active. Time spent in moderate to vigorous physical activity was presented as means of minutes per day

Trial Locations

Locations (2)

Universidad Europea; 🇪🇸 Villaviciosa de Odon, Madrid, Spain

Hospital Infantil Universitario Niño Jesús; 🇪🇸 Madrid, Spain