Clinical Trial of Autologous Adipose Tissue Derived Stromal Cell Therapy for Ischemic Heart Failure
试验速览
- 阶段
- 不适用
- 入组人数
- 6
- 试验地点
- 2
- 主要终点
- all cause harmful events
研究概览
简要总结
Mesenchymal stem cells have capability to differentiate into myocardium, vascular endothelial cell, vascular smooth muscle cell and will be useful for heart regeneration. Adipose tissue is relatively enriched with mesenchymal stem cell compared to bone marrow tissue. In this trial, eligible ischemic heart failure patients will be proceeded intracoronary administration of autologous adipose tissue derived stromal cells by cardiac catheterization.
详细描述
The population of the ischemic heart failure patients is enormous in Japan and the only radical treatment for them is heart transplantation: however, the number of giving donor is extremely limited. Mesenchymal stem cells have been capable to differentiate into mesodermal-lineage cells as well as endodermal-lineage cells such as myocardial cell. They reside in the mesenchymal tissues such as bone marrows as well as adipose tissues. The latter tissues are relatively enriched with mesenchymal stem cells compared to bone marrow cells. In this study, the ischemic heart failure patients will undergo intracoronary administration of autologous adipose tissue derived stromal cells through cardiac catheterization.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Heart failure patients occured by prior ischemic event whose ejection fraction must be less than 40%.
排除标准
- •Complicated severe other organ disease.
- •Patient with malignancy.
- •History of chemotherapy or irradiation within 4 weeks.
- •Patient with immunodeficiency
- •Pregnancy or possibility of pregnancy
- •Candidate who are judged to be not applicable to this study by doctors.
研究组 & 干预措施
adipose tissue derived stromal cells
干预措施: adipose tissue derived stromal cells dosage (Biological)
结局指标
主要结局
all cause harmful events
时间窗: 6 month
次要结局
未报告次要终点
研究者
Shuichi Kaneko
Professor
Kanazawa University