Vitreous Inflammation in Standard and Heavy Silicone Oil
- Conditions
- Vitreous Inflammation
- Interventions
- Device: Vitreous Tamponade with Silicone Oil
- Registration Number
- NCT02675543
- Lead Sponsor
- Università degli Studi di Brescia
- Brief Summary
The inflammatory response after prolonged retinal detachment and after vitreoretinal surgery has its apex in the development of PVR that occurs when retinal cells are exposed to the inflammatory milieu in the humor vitreous.
This situation is common in complicated retinal detachment, but is amplified after invasive surgery and by the use of intraocular tamponades that float over a subtle film of liquid where the inflammatory cytokines and growth factors reach the critical concentration over the inferior retina.
Many authors have noted that the heavy tamponade are more prone to cause intraocular inflammation compared to standard silicone oil, especially if they remain for several months in the eye.
The purpose of this study is to measure the vitreous concentration of some of the most important cytokines involved in the inflammatory vitreal response.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 70
- patient scheduled for vitrectomy
- diabetic retinopathy
- uveitis
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Heavy silicone oil Vitreous Tamponade with Silicone Oil after vitreous removal, the vitreous chamber was filled with heavy silicone oil (Densiron 68) Standard silicone oil Vitreous Tamponade with Silicone Oil after vitreous removal, the vitreous chamber was filled with standard silicone oil (PDMS)
- Primary Outcome Measures
Name Time Method Vitreous Prostaglandin E2 Levels intraoperarive
- Secondary Outcome Measures
Name Time Method