Point-of-care testen van CRP en procalcitonine bij urineweginfecties in verpleeghuize
Recruiting
- Conditions
- rinary tract infectionUrineweginfectie
- Registration Number
- NL-OMON27528
- Lead Sponsor
- Academical Medical Center
- Brief Summary
Kuil SD, Hidad S, Fischer JC, et al. Sensitivity of point-of-care testing C-reactive protein and procalcitonin to diagnose urinary tract infections in Dutch nursing homes: PROGRESS study protocol. BMJ Open 2019;9:e031269. doi:10.1136/bmjopen-2019-031269.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 440
Inclusion Criteria
Nursing homes residents clinically suspected of a urinary tract infection at the discretion of the attending physician
- Provided pre-emptive informed consent
Exclusion Criteria
- Suspected respiratory tract infection OR suspected other infection requiring antibiotic therapy
- Previous inclusion in the past 30 days
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Sensitivity of the point-of-care (POC) test to identify patients with true UTIs, as derived from Receiving Operating Curves (ROC). <br><br /><br /><br>As there is no uniform definition of an UTI, a ‘true UTI’ is defined post-hoc using stringent criteria, including microbiology results and clinical response to adequate antibiotic therapy.<br /><br>The following definition is defined:<br /><br>1.Presence of at least 2 urinary (dysuria, urgency or frequency, new or worsened incontinence, suprapubic or costovertabral angle tenderness) OR non-specific (fever, confusion, delirium, anorexia, malaise) symptoms; AND<br>2.Positive urine leucocyte esterase tests AND<br /><br>3.The presence of a uropathogen in urine at >10E4 CFU/mL (maximum of 2 uropathogens) AND<br /><br>4.Symptom resolution in the course of adequate antibiotic treatment, where adequate treatment is defined by proven susceptibility of isolated uropathogens to the administered antibiotic.
- Secondary Outcome Measures
Name Time Method An LQAS-classification into high versus low AMR prevalence using pre-defined<br>thresholds. Different thresholds for high and low prevalence will be tested<br>Barriers and facilitators for the adoption and implementation of the POC-test.