Surveillance studie naar het voorkomen antibioticaresistentie bij uropathogenen in het verpleeghuis

Recruiting

Conditions: rinary tract infectionUrineweginfectie

Registration Number: NL-OMON26041

Lead Sponsor: Academical Medical Center (AUMC)

Brief Summary: Kuil SD, Hidad S, Fischer JC, et al. Sensitivity of point-of-care testing C-reactive protein and procalcitonin to diagnose urinary tract infections in Dutch nursing homes: PROGRESS study protocol. BMJ Open 2019;9:e031269. doi:10.1136/bmjopen-2019-031269.

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 600

Inclusion Criteria

Elderly nursing home residents and elderly residents of rehabilitation wards (= 65 year) with suspected urinary tract infection based on the attending physician’s medical judgement
No objection on participation by representative or nursing home resident

Exclusion Criteria

Previous inclusion in the past 30 days
Suspected respiratory tract infection
Suspected other infection in need of antibiotic treatment

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To use LQAS-based surveillance for providing AMR prevalence for selected antimicrobials in patients with suspected UTI

Secondary Outcome Measures

Name	Time	Method
To identify barriers and facilitators for implementation of LQAS based surveillance in nursing homes and the use of LQAS-based surveillance data to inform local empirical antimicrobial treatment.<br><br>To describe differences in frequencies of bacterial contamination, bacterial overgrowth and UTIs between spontaneously voided urine samples and urine collected from diapers/incontinence pads in elderly with suspected UTI, suffering from urine incontinence<br><br>To assess the role of general signs and symptoms as predictors for UTIs in elderly nursing home residents<br><br>To understand the emergence and spread of AMR within nursing homes by molecular epidemiological analyses using whole genome sequencing of bacterial isolates from urine<br>