EFFECTS OF ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS ON AMBULATORY BLOOD PRESSURE AND CARDIOVASCULAR FUNCTION IN HYPERTENSIVE PATIENTS ON CONTINUOUS AMBULATORY PERITONEAL DIALYSIS.
Phase 4
- Conditions
- Hypertension, end-stage renal disease on peritoneal dialysis
- Registration Number
- JPRN-UMIN000000665
- Lead Sponsor
- Department of Medical Science and Cardiorenal Medicine, Yokohama City University School of Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Not provided
Exclusion Criteria
Malignancy, overt heart failure, acute myocardial infarction, collagen disease, acute renal failure, hyperkalemia, Pregnant women, or women suspected of being pregnant, history of hypersensitivity to valsartan or candesartan, severe hepatic disease
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1) body weight, residual urinary volume. 2) casual blood pressure. 3) ambulatory blood pressure profile, blood pressure variability. 4) cardiac ultrasonography (IVSd, LVDd, LVPWd, LVDs, FS, EF(modified simpson method), E/A, DcT, etc). 5) ABI/baPWV. 6) blood parameters. CBC: Hb, Ht, fibrinogen Biochemistry: TP, Alb, BUN, s-Cr, UA, Na, K, Cl, Ca, P, GOT, GPT, Alp, T-bil, T-cho, HDL, LDL, TG, beta2-microglobulin. Endocrine: cathecholamine, PRA, PAC, ANP, BNP. Serological: CRP. 7) ECG. 8) Chest Xp. 9) Weekly erythropietin dosage.
- Secondary Outcome Measures
Name Time Method