The effects of angiotensin II receptor blockers (ARBs) on oxidative stress and atherosclerosis in patients with hypertension.
Not Applicable
- Conditions
- Patients with hypertension
- Registration Number
- JPRN-UMIN000001300
- Lead Sponsor
- Second Department of Internal Medicine, Nagasaki University School of Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 120
Inclusion Criteria
Not provided
Exclusion Criteria
Severe liver, renal or respiratory diseases Active infectious and inflammatory diseases Acute phase of heart failure Unstable angina Secondary hypertension
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The effects of ARBs on the parameters listed below at baseline, 3, 6, and 12 months after the administrations. (1) Blood samples (lipid profiles, glucose tolerance, high-sensitive CRP, BNP, etc.) (2) Oxidative stress marker (8-OHdG, 8-isoprostane, etc.) (3) Electrocardiography (4) Echocardiography (5) Carotid ultrasonography (6) Pulse wave velocity
- Secondary Outcome Measures
Name Time Method Evaluation of newly developed oxidative stress marker, such as oxidative LDL (negatively charged LDL) and glutathionylated protein