Long-Term Outcomes in the Treatment of Infantile and Acquired Esotropia With Botulinum Toxin

Completed

Brief Summary: To investigate long-term treatment outcomes of patients receiving botulinum toxin A therapy for infantile and acquired esotropia.

Detailed Description: Participants: 164 patients with infantile esotropia and 89 patients with acquired esotropia.

Methods: Patients were injected with botulinum toxin into two medial rectus muscles and followed from 1992 to 2005. Patients were evaluated at 1 week, 2, 6 and 12 months, and then yearly post-injection.

Main Outcome Measures: Degree of motor alignment, recurrence rate, incidence of stereopsis, and dissociated vertical deviation along with complications.

Recruitment & Eligibility

Inclusion Criteria

Exclusion Criteria

exotropia, high AC/A ratio accommodative esotropia, patients with neurological deficit including cerebral palsy, Down syndrome and mental retardation, and ocular anomalies including retinopathy of prematurity. Patients lost to follow-up at 6 months or less after the last injection were also excluded.

Primary Outcome Measures

Name	Time	Method
Degree of motor alignment, recurrence rate, incidence of stereopsis, and dissociated vertical deviation along with complications.	Before treatment, weekly after the treatment, and monthly after motor alignment

Secondary Outcome Measures

Name	Time	Method

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