Effect of Protein From Animal and Vegetable Sources on Appetite

Not Applicable

Completed

• Conditions: Focus of Study: Appetite
• Interventions: Other: Vegetable Protein; Other: Animal protein

• Registration Number: NCT01345487
• Lead Sponsor: Arne Astrup

Brief Summary

New Nordic diet guidelines advocate a reduction in consumption of protein from animal sources such as beef and pork, due to environmental concerns. Instead, intake of protein from vegetable sources such as legumes and pulses should be increased. However, little is known about the effect of protein from (Nordic grown) beans and peas on body weight and appetite regulation.

The objective of this study is to examine if protein from vegetable sources (beans and peas) is comparable to protein from animal sources regarding acute meal-induced satiety.

Detailed Description

Design:

Single-blind randomized 3-way crossover meal study

Subjects:

* 48 young healthy men (Age: 18-50 years; BMI: 19-30 kg/m2).

* Expected completers: n=42.

End points:

* Subjective appetite (VAS) (every 30 min for 3 hours)

* Ad libitum energy intake (3 hours after test meal)

Experimental diets:

Iso-caloric breakfast meals (3.5 MJ) with same energy density:

A. Fava beans + Split peas (20 protein E%) B. Fava beans + Split peas + potato (10 protein E%) C. Pork/beef + potato (20 protein E%)

Study Timeline

• Study Start: 2011-04
• Study First Submitted: 2011-04-27
• Study First Submitted QC: 2011-04-28
• Study First Posted: 2011-05-02
• Primary Completion: 2011-06
• Study Completion: 2011-07
• Status Verified: 2015-03
• Last Update Submitted: 2015-03-24
• Last Update Posted: 2015-03-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 48

Inclusion Criteria

• healthy men
• 18-50 y
• body mass index (BMI) 18.5-30.0

Exclusion Criteria

• smoking
• participation in other studies for 4 mo prior to entry
• weight gain/loss > 3 kg for to mo prior to entry
• Strenuous physical activity for > 10 h/wk
• Use of medication that can affect appetite
• food allergies or relevance for the test meals
• Psychiatric or metabolic disorders prohibiting participation

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Low Vegetable Protein	Vegetable Protein	Meal with 10 E% protein from fava beans/split peas
High Vegetable protein	Vegetable Protein	Meal with 20 E% protein from fava beans/split peas
High Animal Protein	Animal protein	Meal with 20 E% protein from pork/beef

Primary Outcome Measures

Name	Time	Method
Ad libitum energy intake	Assessed 180 min after each of the 3 test meals, which are served 1 wk apart	180 min after each test meal an ad libitum meal of spaghetti bolognese is served, and the total energy intake is recorded.
Composite appetite score area under the curve (180 min)	Assessed every 30 min for 180 min after each of the three test meals which are served 1 wk apart	Composite score calculated from 10 cm visual analogue scale ratings: (desire to eat + hunger + prospective food consumption + (100-fullnes) + (100-satiety))/5

Secondary Outcome Measures

Name	Time	Method
Appetite ratings	Assessed every 30 min for 180 min after each or the 3 test meals which are served 1 wk apart	Assessment of hunger, fulness, satiety, desire to eat and prospective food consumption from 10 cm visual analogue scale ratings every 30 min after meal consumption for 3 hours.

Trial Locations

Locations (1)

Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen; 🇩🇰 Frederiksberg C, Denmark