Effect of Protein From Animal and Vegetable Sources on Appetite
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 48
- Locations
- 1
- Primary Endpoint
- Composite appetite score area under the curve (180 min)
Study Overview
Brief Summary
New Nordic diet guidelines advocate a reduction in consumption of protein from animal sources such as beef and pork, due to environmental concerns. Instead, intake of protein from vegetable sources such as legumes and pulses should be increased. However, little is known about the effect of protein from (Nordic grown) beans and peas on body weight and appetite regulation.
The objective of this study is to examine if protein from vegetable sources (beans and peas) is comparable to protein from animal sources regarding acute meal-induced satiety.
Detailed Description
Design:
Single-blind randomized 3-way crossover meal study
Subjects:
- 48 young healthy men (Age: 18-50 years; BMI: 19-30 kg/m2).
- Expected completers: n=42.
End points:
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Prevention
- Masking
- Single (Outcomes Assessor)
Eligibility Criteria
- Ages
- 18 Years to 50 Years (Adult)
- Sex
- Male
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •healthy men
- •body mass index (BMI) 18.5-30.0
Exclusion Criteria
- •participation in other studies for 4 mo prior to entry
- •weight gain/loss > 3 kg for to mo prior to entry
- •Strenuous physical activity for > 10 h/wk
- •Use of medication that can affect appetite
- •food allergies or relevance for the test meals
- •Psychiatric or metabolic disorders prohibiting participation
Arms & Interventions
Low Vegetable Protein
Meal with 10 E% protein from fava beans/split peas
Intervention: Vegetable Protein (Other)
High Vegetable protein
Meal with 20 E% protein from fava beans/split peas
Intervention: Vegetable Protein (Other)
High Animal Protein
Meal with 20 E% protein from pork/beef
Intervention: Animal protein (Other)
Outcomes
Primary Outcomes
Composite appetite score area under the curve (180 min)
Time Frame: Assessed every 30 min for 180 min after each of the three test meals which are served 1 wk apart
Composite score calculated from 10 cm visual analogue scale ratings: (desire to eat + hunger + prospective food consumption + (100-fullnes) + (100-satiety))/5
Ad libitum energy intake
Time Frame: Assessed 180 min after each of the 3 test meals, which are served 1 wk apart
180 min after each test meal an ad libitum meal of spaghetti bolognese is served, and the total energy intake is recorded.
Secondary Outcomes
- Appetite ratings(Assessed every 30 min for 180 min after each or the 3 test meals which are served 1 wk apart)
Investigators
Arne Astrup
M.D
University of Copenhagen