To Compare Two Different Modes of Corneal Collagen Cross Linking for Strenghtening Cornea in Keratoconus
- Conditions
- Health Condition 1: null- keratoconus and corneal ectatic conditions
- Registration Number
- CTRI/2015/06/005926
- Lead Sponsor
- ethradhama Superspeciality eye Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 100
•Worsening of uncorrected distance visual acuity (UDVA) or best corrected distance visual acuity (BDVA) of > 0.50 Snellen lines
•Increase of manifest spherical or cylindrical refractive error of > 0.50 Diopter
•Increase in steepest keratometry value (on Sim K or Manual) by >=1D
•Increase in mean K reading >= 1â??D
•Reduction of the thinnest point at corneal optical coherence tomography (OCT) pachymetry >=10â??μm
•Thin corneas ( Corneal pachymetry at thinnest point < 400um)
•Prior herpetic infection because it may result in viral reactivation
•Concurrent infection
•Severe corneal scarring or opacification
•History of poor epithelial wound healing
•Severe ocular surface disease ( moderate to severe dry eyes Schirmer test I < 10 mm)
•Autoimmune disorders
•Pregnant and nursing mother
•Previous intraocular and corneal surgery
•Glaucoma or IOP higher than 24mmHg
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the pulsed mode with the continuous mode of accelerated corneal collagen cross linking (KXL) in terms of efficacy and safety for keratoconus.Timepoint: Follow-up on day 1, ady 5, day 30 , 3 months and 6 months post-operatively.
- Secondary Outcome Measures
Name Time Method To assess the quality to vision and post-operative complications if any.Timepoint: Follow-up on day 1, ady 5, day 30 , 3 months and 6 months post-operatively.