The effects of atomoxetine on brain potentials in response to auditory distracting sounds during driving in adults with attention-deficit hyperactivity disorder.
Recruiting
- Conditions
- ADHD, atomoxetine, electroencephalography (EEG), event-related potential (ERP), attention, inhibition
- Registration Number
- NL-OMON24935
- Lead Sponsor
- trecht UniversityFaculty of ScienceDepartment of Psychopharmacology
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 30
Inclusion Criteria
1. Adult men and women diagnosed with ADHD (DSM IV, APA 1994), aged 21-55 years;
2. Written informed consent;
Exclusion Criteria
1. Depression or anxiety disorder, unless controlled and stable with medication (SSRI);
2. IQ<75;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Primary outcome measures are:<br /> <br>The weaving of the car during the driving test, i.e. the Standard Deviation of Lateral Position (SDLP), the P3a measured in an auditory oddball task which is suggested to reflect attention orienting/distraction, and the stop signal reaction time and P3 measured in a stop task which is suggested to be associated with response inhibition.
- Secondary Outcome Measures
Name Time Method Secondary outcome measures are:<br /><br>Mean speed, meen lateral position, and Standard Deviation of Speed (SDS) for the driving test.<br><br>Mismatch negativity (MMN), P3b and reorienting negativity (RON), reaction times, false alarms, and misses for the auditory oddball task.<br><br>N1, mean reaction time, reaction time variability, percentage correctly inhibited, percentage errors, and percentage ommisions in the stop task.