CTRI/2025/07/091893尚未招募2/3 期
Comparison of different time intervals between fentanyl and thiopentone on entropy guided induction dose of thiopentone in adult patients under general anaesthesia
Dr Anjali yadav1 个研究点 分布在 1 个国家目标入组 132 人开始时间: 2025年8月6日最近更新:
试验速览
- 阶段
- 2/3 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 132
- 试验地点
- 1
- 主要终点
- Total dose of thiopentone required for induction of anaesthesia in the groups.
研究概览
简要总结
This study aims to evaluate how varying time interval between the administration of fentanyl and thiopentone affects the induction dose of thiopentone required, as guided by entropy monitoring, in adult patients undergoing general anaesthesia. By comparing different time gaps between these two drugs, the study seeks to optimise drug dosing for safer and more effective anaesthesia induction. Secondary outcomes include the incidence of abnormal movements and changes in vital parameters such as heart rate, oxygen saturation, and blood pressure during induction.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 盲法
- None
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •ASA grade: American society of Anaesthesiologists physical status grade I- II scheduled for elective surgery under general anaesthesia.
排除标准
- •1.Known allergic reactions to sulpha group drugs.
- •2.Patients on drugs which are likely to interfere with induction agent or hemodynamic parameters.
- •3.Neurology or neurosurgery patients.
- •4.Patients posted for emergency surgery.
结局指标
主要结局
Total dose of thiopentone required for induction of anaesthesia in the groups.
时间窗: 0- 10 minutes after thiopentone administration.
次要结局
- 1.The incidence of abnormal movement after the initial dose of thiopentone.(2.The incidence of heart rate, oxygen saturation, and blood pressure variations in these patients.)
研究者
Dr. Anjali Yadav
Abvims and Dr. rml hospital
研究点 (1)
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