Tolerance induction in cow's milk allergy

Completed

• Conditions: Cow's milk allergy/ Cow's milk protein allergy; 10001708

• Registration Number: NL-OMON30721
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 90

Inclusion Criteria

Child
Cow's milk allergy diagnosed by double blind, placebocontrolled randomised foodchallenge

Exclusion Criteria

immune-mediated disease

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The percentage of infants who develop tolerance at each outpatient day clinic<br /><br>visit (OPD), determined by a DBPCFC.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The incidence and severity of asthma and allergic rhinitis.<br /><br>Serum Total IgE, IgG and IgG4 concentration.<br /><br>Newly acquired sensitizations, measured by specific IgE for the most prevalent<br /><br>food-and inhalant allergens.<br /><br>Peripheral blood derived T-cell phenotype, antigen-specific proliferation and<br /><br>cytokine production and/or expression of intracellular transcription factors<br /><br>specific for regulatory T-cells and cytokine production.<br /><br>Stool samples will be studied for identification and quantification of<br /><br>micro-organisms.</p><br>