Effect of High-Intensity Interval Training Compared to Hydrochlorothiazide on Ambulatory Blood Pressure, Cardiovascular Health, Cognition and Mobility in Pre-Hypertensive Older Adults.
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- 24h-Ambulatory Blood Pressure
研究概览
简要总结
The number of persons with hypertension is increasing and with it the number of related cardiovascular events and related functional or cognitive declines. While studies have suggested that physical activity, in particular, high-intensity interval training (HIIT), could be as efficient as the commonly used antihypertensive medications, no studies have actually compared their effects in the same population. This protocol will determine if HIIT is at least as efficient as hydrochlorothiazide in order to lower 24h-ambulatory blood pressure (BP) in prehypertensive older adults.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age at consent ≥ 60 years;
- •Systolic Blood pressure measured through BPtru™ between SBP ≥ 120 mmHg and < 140 and or DBP ≥ 80 mmHg
- •Being able to sign the informed consent form
排除标准
- •Considered "highly active" according to the International Physical Activity Questionnaire
- •Practicing more than 20 min per week of High-Intensity Interval Training
- •Use of antihypertensive medication
- •Contraindication for the practice of intense physical activity
- •Functional limitations related to the exercise test and to intensive training
- •Cardiovascular pathology
- •Atrial fibrillation
- •Psychiatric or neurological disorder
- •Renal failure
- •MMSE score < 26
- •Persons benefiting of enhanced protection: persons deprived of their liberty by a judicial or administrative decision, persons staying in a health or social institution, adults under legal protection and patients in emergency situations.
研究组 & 干预措施
High Intensity Interval Training (HIIT)
For the twelve weeks of intervention, participants will have three training sessions per week. Each session will be done on a cycle ergometer and will last approximately 40 minutes. Participants will be supervised by certified kinesiologists and their training programs will be revised every four weeks.
干预措施: 24h-Ambulatory Blood Pressure (Other)
HydroChloroThiazide
For this group, participants have to take a diuretic (12,5 mg of Hydrochlorothiazide) daily prescribed by the doctor of this study, for twelve weeks. Participants should also maintain the same lifestyle habits that they had before the study.
干预措施: 24h-Ambulatory Blood Pressure (Other)
结局指标
主要结局
24h-Ambulatory Blood Pressure
时间窗: At baseline and after twelve weeks of intervention
The 24-hour ambulatory measure of the blood pressure (AMBP)
次要结局
- Cardiovascular evaluation(Before and after twelve weeks of intervention)
- Cognitive functions(Before and after twelve weeks of intervention)
- Flow Mediated Dilatation (FMD)(Before and after twelve weeks of intervention)
研究者
Anil Nigam
MD, cardiologist
Montreal Heart Institute