Cardiovascular Effects of High-Intensity Interval Training (HIIT) and Moderate-Intensity Continuous Training (MCT)
Overview
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- University of Delaware
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- Blood Pressure
Overview
Brief Summary
The purpose of this study is to determine the effect of high-intensity interval training (HIIT) in comparison to moderate-intensity continuous training (MCT) on blood pressure, blood vessel function, and blood pressure reactivity.
Detailed Description
It is estimated that one-third of the adult population in the United States has blood pressure values that are classified as prehypertension. This slight elevation in blood pressure has been shown to result in an increased risk for developing hypertension and cardiovascular disease. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC7) recommends lifestyle modifications for individuals classified as prehypertensive. One lifestyle modification suggested by JNC7 is regular physical activity. Aerobic exercise, like moderate-intensity continuous training (MCT), has been shown to improve blood pressure, blood vessel function, and arterial stiffness in those with prehypertension. However, a major barrier to exercise adherence is the time commitment required. High-Intensity Interval Training (HIIT), which requires individuals to work at higher intensities for shorter durations, may offer an alternative training design that would reduce the time commitment. Previous studies have shown HIIT to be equal to or better at improving cardiorespiratory fitness and blood vessel function in multiple populations. Limited information is present on HIIT training in those with prehypertension. In this study, participants will be randomized into one of the two training program designs mentioned above (MCT or HIIT). Both programs will be completed over an 8-week period (3 sessions per week) and each training session will be supervised. Participants will complete testing visits before and after the training program to collect measures of cardiovascular health (exercise capacity, blood pressure, blood vessel function, and blood pressure reactivity). The goal is to compare the effects of the training programs on these measures of cardiovascular health.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 20 Years to 44 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Blood Pressure less than 140/90 mmHg
- •Sedentary
Exclusion Criteria
- •Known or major signs/symptoms of cardiovascular, pulmonary, renal, or metabolic disease
- •Use of antihypertensive medication
- •Current tobacco use
- •BMI (body mass index) less than 30 kg/m2
- •Postmenopausal
- •Current pregnancy
- •Current hormone replacement therapy
- •Participating in regular aerobic exercise at least three times a week for 30 minutes at a moderate intensity for the past 3 months or more
- •Not able to regularly exercise for any reason
Outcomes
Primary Outcomes
Blood Pressure
Time Frame: Change from baseline resting blood pressure at 8 weeks
Resting blood pressures measuring by automated oscillometric device
Secondary Outcomes
- Pulse Wave Analysis(Change from baseline central blood pressure measures at 8 weeks)
- Arterial stiffness(Change from baseline pulse wave velocity measures at 8 weeks)
- Peak Aerobic Capacity(Change from baseline VO2peak at 8 weeks)
- 24-Hour Ambulatory Blood Pressure(Change from baseline 24-hour ambulatory blood pressure at 8 weeks)
- Endothelial Function(Change from baseline endothelial function at 8 weeks)
- Blood Pressure Reactivity(Change from baseline blood pressure reactivity at 8 weeks)
Investigators
David Edwards
Professor
University of Delaware