Effects of High-intensity Interval Training on Myocardial Strain in Patients With Metabolic Syndrome
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- High-Intensity Interval Training
- Sponsor
- University of Castilla-La Mancha
- Enrollment
- 80
- Locations
- 1
- Primary Endpoint
- Changes in global longitudinal strain
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
the effects of high-intensity interval training on myocardial function will be studied in a group of patients under medical treatment for the components of metabolic syndrome.
Detailed Description
Objective: To analyze the effects of high-intensity interval training (HIIT) on myocardial function of metabolic syndrome patients. Methods and design. Randomized clinical trial with a control group. Project was developed in association with the regional general hospital. Pre and post-intervention evaluation after 16 weeks of training for the HIIT group. Subjects: Recruited using adverts published on public medical center boards. Up to 30 subjects per group (HIIT and CONTROL) will be recruited (at least 20% women) Measurements. Echocardiography: Global longitudinal strain (GLS), Mitral filling parameters, myocardial dimensions, and myocardial wall thickness. Cardiorespiratory fitness: Maximal oxygen consumption, Maximal power output, Maximal oxygen pulse. Clinical: Metabolic syndrome components and derived variables (e.g., triglycerides/high-density lipoprotein ratio) Body composition by anthropometric measurements and dual-energy X-ray absorptiometry.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Clinical diagnosis of metabolic syndrome.
- •Capacity to exercise on a stationary bike
- •Inhabitant of the province of Toledo
Exclusion Criteria
- •Untreated cardiovascular disease with hemodynamic instability
- •Untreated respiratory disease, symptomatic.
- •Untreated metabolic disease.
- •Untreated renal disease requiring dialysis.
- •Contraindications for high-intensity exercise training
Outcomes
Primary Outcomes
Changes in global longitudinal strain
Time Frame: up to 16 weeks
response to myocardial strain after intervention. Assessed by echocardiography, measured as a percentage
Secondary Outcomes
- changes in cardiorespiratory fitness(up to 16 weeks)
- changes in metabolic syndrome z-score(up to 16 weeks)
- changes in estimated left ventricle filling pressures (E/e')(up to 16 weeks)
- changes in visceral fat(up to 16 weeks)
- changes in left ventricle passive filling (E wave)(up to 16 weeks)
- changes in early diastolic mitral annulus velocity (e' wave)(up to 16 weeks)