Is exhaled propofol concentration influenced by mechanical ventilation settings?

Not Applicable

• Conditions: Elective surgical procedure; E04.249

• Registration Number: JPRN-jRCT1032230398
• Lead Sponsor: Masui Kenichi

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-10-16
• Last Update Posted: 20 November 2023

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

1) 30 scheduled surgery patients aged 18 and over who are hospitalized at Yokohama City University
Hospital (10 aged 18-49, 10 aged 50-69, 10 aged 70 and over. 5 males and 5 females in each age group)
2) Patients who are expected to undergo general anesthesia for more than 3 hours
3) Supine position, general anesthesia patient under double lung ventilation
4) Patients undergoing invasive arterial pressure catheter insertion
5) Patients who have given their written consent to participate in this study

Exclusion Criteria

1) Patients contraindicated for administration of propofol
2) Patients whose ASA classification, which is the general condition classification of the American Society of Anesthesiologists, is class 4 or higher
3) Surgery with head low or high at 25 degrees or more
4) Patients with interstitial pneumonia, COPD, pulmonary edema, severe cardiac dysfunction, severe liver
dysfunction
5) Pregnant women (lactating women)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Prediction Error (PEex) calculated using estimated end tidal expiratory propofol concentration and measured plasma propofol. PEex is defined as (measured plasma propofol concentration - end tidal propofol concentration)/end tidal propofol concentration or measured plasma propofol concentration/end tidal propofol concentration.