Total Serum Ig E levels before and after treatment in patient having ringworm and its relation withdisappearance and reappearance of ringworm.
- Conditions
- Health Condition 1: B359- Dermatophytosis, unspecified
- Registration Number
- CTRI/2020/05/025191
- Lead Sponsor
- GCS Medical College Hospital and Research Centre
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
1)Patients of either sex age between 18 to 60 years.
2)Presence fungus in scrapping taken from lesion by in KOH preparation.
3)Women of child bearing age must have a negative urine pregnancy test.
4)Patient willing to give written informed consent for study Exclusion criteria.
1)Patient less than 18 years age and more than 60 years.
2)Pre-existing Cardiovascular, pulmonary, hepatic, renal, haematological, gastrointestinal, endocrine, immunologic, musculoskeletal, neurological or psychiatric disease.
3)Major surgical or medical illness in last 4 weeks before screening.
4)Any concomitant medication for purpose other than dermatophytosis management at presentation or within last 4 weeks before screening.
5)Any concomitant intake of herbal, homeopathic or other alternative therapy at presentation or within last 4 weeks before screening.
6)Alcohol dependence, alcohol abuse or drug abuse within past one year.
7)Moderate to heavy smoking ( >10 cigarettes/day) or consumption of tobacco products
8)Clinically significant illness within 4 weeks before the start of the study
9)Asthma, urticaria or other allergic type reactions after taking any medication
10)Past History of atopy, Family history of atopy in first degree relatives.
11)Pregnant and lactating women
12)Patient having pre-existing medical condition (DM HT or any other medical condition requiring concomitant medicine.) or diagnosed during screening.
13)Clinically diagnosed as dermatophytic skin infection but negative for fungus in KOH examination.
14)Dermatophytosis independently or concomitantly involving scalp (T. Capitis), nail (onychomycosis), palm (T. pedis) and sole (T. mannum).
15)Patients having skin lesions with secondary bacterial infections.
16)Past or present history of atopy including any type of eczema, H/o contact sensitization, Allergic rhinitis or Asthma.
17)HIV Hepatitis B, C positive patients.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method -To study clinical cure rate by achieving grade 3 in grades of improvement and grade 4 in physician global assesement of disease activity in patient of dermatophytosis and itâ??s association with pre and post total serum IgE . <br/ ><br>- To study mycological cure rate by achieving KOH mount negative at end of 2 months <br/ ><br>-To study relapse rate of clinical and mycological relapse rate in patient with dermatophytosis at end of 2 months and itâ??s association with pre and post total serum IgETimepoint: 2 months
- Secondary Outcome Measures
Name Time Method To check the association of study parameters with other clinical parameters like prior use of topical and systemic steroids and its association with seum Ig E.Timepoint: 1 year