Do synbiotics reduce infections after bowel surgery?

Not Applicable

Recruiting

• Conditions: Colorectal disease; Postoperative infection; Colorectal cancer; Inflammatory bowel disease; Surgery - Other surgery; Infection - Studies of infection and infectious agents; Oral and Gastrointestinal - Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colon; Oral and Gastrointestinal - Inflammatory bowel disease; Cancer - Bowel - Back passage (rectum) or large bowel (colon)

• Registration Number: ACTRN12623001315606
• Lead Sponsor: The University of Auckland

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2023-12-15
• Last Update Posted: 5 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 190

Inclusion Criteria

Adult patients undergoing elective colorectal resection for malignant or benign conditions at selected trial sites in New Zealand.
- Elective colorectal resection includes surgical planning for anastomosis +/- stoma formation.

Exclusion Criteria

- Patients undergoing acute or emergency operation
- Patients not receiving an anastomosis
- Patients undergoing surgical planning to remove all of their colon
- Not enough time for patient to have 3 days or more preoperative powder (due to short time-frames between clinic and date of surgery)
- Intolerance to probiotics or synbiotics
- Unwilling to provide informed consent after discussions held in the participant's preferred language
- Development of acute pancreatitis during the clinical trial
- Severe immunosuppression with neutrophils less than 1 prior to enrollment in the clinical trial

Study & Design

• Study Type: Interventional
• Study Design: Not specified