Effect of Synbiotics on Postoperative Delirium after Elective Cardiac Surgery
- Conditions
- Cardiac valvular disease, coronary artery diseaseCardiac valvular disease, coronary disease
- Registration Number
- JPRN-jRCTs051210080
- Lead Sponsor
- Yoshitani Kenji
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 184
1)Patients with elective cardiac surgery with cardiopulmonary bypass
2)Patietns with entry more than 10 days before surgery
3)Patients more than 65 years old.
4)Patients with informed consent by myself
1) Patients who cannot stop taking other supplement such as symbaiotics or probiotics during test period.
2) Patents with preoperative ICDSC no more than 3, or MMSE no less than 21
3) Patients who cannot take test symbiotics or placebo due to allegry or diffulty of oral ingestion.
4) Patients with left ventricle assist device.
5) Patient with corticobasal degeneration disease.
6) Patients with history of craniotomy
7) Patients with antipsychotic agent
8) Patients who is diagnosed as dimentia and received standard therapy
9) Patiemts daignosed as infectious myocarditis
10) Patients with stoma
11) Patients diagnosed as inflammatory bowel disease(Crohn disease, ulcerative colitis) and receiving standard therapy
12) Patients diagnosed as collagen disease and receiving standard therapy
13) Patients receiving antibiotics within 2 weeks prior to obtaining consen.
14) Patients participating other clinical traial or shceduled to be enrolled in the other clinical trial.
15) Patients deemed to be unsuitable to be enrolled into this study due to other specific reason.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Association between symbiotics and the incidence of postoperative delirium in postoperative one week
- Secondary Outcome Measures
Name Time Method