The effects of bisphosphonates on disease activity and bone status in ankylosing spondylitis (BIAS)
Completed
- Conditions
- Ankylosing Spondylitis (AS)Musculoskeletal Diseases
- Registration Number
- ISRCTN87639321
- Lead Sponsor
- Royal National Hospital for Rheumatic Diseases (UK)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 180
Inclusion Criteria
Age > 21, stable dose of non-steroidal anti-inflammatory drug (NSAID) for last four weeks. Need to fulfil New York Criteria for AS.
Exclusion Criteria
1. Systemic steroids for the last three months
2. Bisphosphonates in the last 12 months
3. Oesophageal disease or active peptic ulcer
4. Unable to give informed consent
5. Known Paget's Disease
6. Renal disease with creatinine >150 mmol/l, hypercalcaemia, osteomalacia, inflammatory bowel disease, known malignancy and reduced life expectancy <2 years
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method BAS-G
- Secondary Outcome Measures
Name Time Method BASDAI, BASFI and BASRI, ESR, CRP, use of NSAIDs, bone density and vertebral deformity.