A study on three dimensional planning using MRI guidance in brachytherapy of locally advanced cancer cervix
- Conditions
- Health Condition 1: null- Cancer of the uterine cervix in whom definitive radiotherapy with curative intent is planned.
- Registration Number
- CTRI/2012/02/002439
- Lead Sponsor
- Medical University of Vienna
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 600
Cancer of the uterine cervix considered suitable for curative treatment with definitive radio-(chemo)therapy including MRI guided BT
Positive biopsy showing squamous-cell carcinoma, adenocarcinoma or adeno-squamous cell carcinoma of the uterine cervix.
Staging according to FIGO and TNM guidelines
MRI of pelvis at diagnosis is performed
MRI, CT or PET-CT of the retroperitoneal space and abdomen at diagnosis is performed
MRI with the applicator in place at the time of (first) BT will be performed
Para-aortic metastatic nodes below L1-L2 are allowed
Patient informed consent
Other primary malignancies except carcinoma in situ of the cervix and basal cell carcinoma of the skin
Metastatic disease beyond para-aortic region (L1-L2)
Previous pelvic or abdominal radiotherapy
Previous total or partial hysterectomy
Combination of preoperative radiotherapy with surgery
Patients receiving BT only
Patients receiving EBRT only
Patients receiving neoadjuvant chemotherapy
Contra indications to MRI
Contra indications to BT
Active infection or severe medical condition endangering treatment delivery
Pregnant, lactating or childbearing potential without adequate contraception
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method local control/morbidityTimepoint: 5 years
- Secondary Outcome Measures
Name Time Method regional control <br/ ><br>disease free survival <br/ ><br>overall survival quality of life (QoL)Timepoint: 5 years