The use of MRI guided focused ultrasound for the management of focal hand dystonia

Not Applicable

Completed

• Conditions: focal hand dystonia; Neurological - Other neurological disorders

• Registration Number: ACTRN12622000775718
• Lead Sponsor: St Vincent's Health Network Sydney

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2022-05-31
• Study Completion: 2024-03-21
• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 11

Inclusion Criteria

Patients will be included based on a formal diagnosis of focal hand dystonia (of either musician’s dystonia or writer’s subtype) as made by a consultant neurologist with specialisation in movement disorders. All patients must be at least 18 years of age and be willing to provide written consent to participate in the study. Patients must have tried and failed first line therapies for focal hand dystonia including hand therapy, oral medications and/or botulinum toxin injections.
All patients must be ambulant at the time of the procedure.

Exclusion Criteria

Patients will be excluded if any of the following criteria are fulfilled
•History of ischaemic stroke or transient ischaemic event
•History of stereotactic cerebral surgery
•Diagnosis of unstable cardiac disease
•Diagnosis of psychiatric disease
•Cognitive impairment as indicated by a mini-mental state examination score of < 24
•Coagulopathy or on anticoagulation that cannot be withheld for the intervention
•Skull density ratio of <0.3
•Absolute contraindication to MRI (eg: non-MR compatible pacemaker/defibrillator or other non-MR compatible device in situ).
•Relative contraindication to MRI (such as severe claustrophobia) will be assessed on a case-by-case basis
•Unwilling to provide written consent

Study & Design

• Study Type: Interventional
• Study Design: Not specified