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Clinical Trials/NCT03206034
NCT03206034
Completed
Not Applicable

Stylistic Memory Enhancement

Kessler Foundation0 sites20 target enrollmentMarch 1, 2013

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Multiple Sclerosis
Sponsor
Kessler Foundation
Enrollment
20
Primary Endpoint
California Verbal Learning Test (CVLT-II- Total learning
Status
Completed
Last Updated
8 years ago

Overview

Brief Summary

Impairments in higher level cognitive processing, such as new learning and memory, are common in Multiple Sclerosis (MS) and negatively impact multiple aspects of everyday life, including occupational and social functioning. Despite this, few studies have attempted to remediate these cognitive deficits in order to improve everyday functioning. While not applied in traditional rehabilitation protocols as of yet, many techniques from cognitive psychology significantly improve learning and memory in healthy persons. These techniques include the generation effect (GE), the spacing effect (SE), and the testing effect (TE). These techniques have recently been incorporated into an 8-session treatment protocol, Stylistic Memory Enhancement (SME), designed to teach participants about each of the techniques, train them on how to apply the techniques in daily life and practice their application to daily life memory demanding situations. The protocol includes teaching participants how to restructure a memory demanding situation in order to make optimal use of self-generation, spaced learning and self-testing. The objective of the study is to test the efficacy of the SME in an MS population.

Registry
clinicaltrials.gov
Start Date
March 1, 2013
End Date
December 31, 2015
Last Updated
8 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Sponsor
Kessler Foundation
Responsible Party
Principal Investigator
Principal Investigator

Nancy Chiaravalloti

Director Neuropsychology and Neuroscience Research

Kessler Foundation

Eligibility Criteria

Inclusion Criteria

  • Clinically definite MS between the ages of 18 and
  • Participants must have impairment in new learning (determined by an in-person screen) with intact language comprehension.

Exclusion Criteria

  • History of alcohol or drug abuse/dependence,
  • Major psychiatric disturbance (e.g. bipolar disorder, schizophrenia) and neurological history other than MS.
  • Corticosteroid use within the last month prior to the participation.
  • Less than 1 month post most recent exacerbation.

Outcomes

Primary Outcomes

California Verbal Learning Test (CVLT-II- Total learning

Time Frame: Baseline and post-intervention (5 weeks between testing sessions)

Measure of change in new learning

Secondary Outcomes

  • Memory Functioning Questionnaire(Baseline and post-intervention ( 5 weeks between testing sessions))

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