Effect of vitamin D supplements in schizophrenia
- Conditions
- SCHIZOPHRENIA.Schizophrenia
- Registration Number
- IRCT20190313043039N1
- Lead Sponsor
- Tabriz University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 46
People with schizophrenia admitted to Razi Hospital
The age range of 18-65 years old in men and the age range of 18-50 years in women
Diagnosis of schizophrenia based on the DSM-V (Diagnostic and Statistical Manual of Mental Disorders, 5th Edition) and Psychiatrist's Confirmation
PANSS score above 70
Did not receive any dietary supplements ( oral or injectable) in the past year(such as vitamin D3 and calcium)
Serum levels of the vitamin D3 below 20 ng / ml
The desire to participate in the study
Pregnancy or breastfeeding
comorbididty with other major psychological or neurological diseases such as bipolar disorder and multiple sclerosis
Smoking and alcohol consumption
History of compliance with certain diets
Use of serum vitamin D suppressants (such as anticonvulsants and glucocorticoids)
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Components of metabolic syndrome including waist circumference, fasting blood glucose, HDL, triglyceride and blood pressure. Timepoint: Before the intervention and 8 weeks later. Method of measurement: Accordingly, the bandwidth (waist circumference), kit and autoanalyser (sugar, HDL and triglyceride) and mercury pressure gauge (blood pressure).
- Secondary Outcome Measures
Name Time Method Serum levels of glycogen synthase kinase 3, beta-catenin, BDNF, S100B and ZAG. Timepoint: Before the intervention and 8 weeks later. Method of measurement: ELISA.