Pentoxifylline in prevention of amphotericin-induced nephrotoxicity and electrolytes imbalances
Phase 2
- Conditions
- Fungal infections.Unspecified mycosis
- Registration Number
- IRCT2016071328901N1
- Lead Sponsor
- Isfahan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Adult patients (over age 18) with malignancy or fever/neuropenia who receive conventional form of Amphotericin for at least one week; patients with CrCl > 60 mL/min.
Exclusion criteria:
Patients who received Amphotericin during two weeks before hospitalization; Patients with mucositis, or any other GI complication who can not tolerate Pentoxiphylline administration; History of reaction to Pentoxiphylline or other Xanthines; Renal insufficiency or electrolyte imbalances at the study beginning.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method ephrotoxicity or Electrolyte imbalances. Timepoint: From day 1 to day 7 during treatment. Method of measurement: Renal indices and Electrolytes.
- Secondary Outcome Measures
Name Time Method