Efficacy of Intramuscular Injection of Calcitonin on Pain & Functional Status of Patients with Knee Osteoarthritis

Phase 2

• Conditions: Osteoarthritis of knee.; Bilateral primary osteoarthritis of knee; M17.0

• Registration Number: IRCT20130518013364N9
• Lead Sponsor: Shahid Beheshti University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2021

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Age between 35-75 years
knee pain during past 6 months
At least two clinical symptoms of joint inflammation based on ACR criteria for osteoarthritis

Exclusion Criteria

unwillingness to participate in the study
History of cardiovascular disease
History of renal disease
History of hepatic disease
History of gastrointestinal disease
History of coagulopathy
History of intra-articular injection into the affected knee within 3 months before
Currently using DMOADS agents (hydroxychloroquine, sulfasalazine, methotrexate, cyclosporine, azathioprine)
Pre-existing allergies to calcitonin
Previous knee arthroplasty
Recent history of substance abuse
Those who cannot report the result reliably due to cognitive impairment

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pain. Timepoint: At the beginning of the study (before the intervention) and two months after. Method of measurement: VAS.;WOMAC Index. Timepoint: At the beginning of the study (before the intervention) and two months after. Method of measurement: The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC).