To evaluate if combination of low dose rocuronium with magnesium sulphate and ketamine provides better intubating conditions at 60 seconds compared to high dose rocuronium alone, in adults.

Phase 2/3

Not yet recruiting

Conditions: Other specified symptoms and signsinvolving the digestive system and abdomen,

Registration Number: CTRI/2020/06/025726

Lead Sponsor: Amrita Hospital

Brief Summary: Rocuronium is a non depolarizing muscle relaxant used for rapid sequence induction in conditions where succinylcholine is contraindicated. In this randomized control study we would be looking forward to find out if combination of low dose rocuronium 0.6 mg/kg IV with magnesium sulphate 30 mg/kg IV and ketamine 1 mg/kg IV provides better intubating conditions at 60 seconds compared to high dose rocuronium 0.9 mg/kg IV alone. We would also be looking at the hemodynamic response between both the groups.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 68

Inclusion Criteria

65 years ASA PS 1-2 BMI 18.5.
24.9 kg/m2 Mallampati grade 1-2 Elective surgery under general anaesthesia requiring intubation.

Exclusion Criteria

Neuromuscualr disease Renal insufficiency Hepatic insufficiency Allergy to study drugs Breast feeding or pregnancy Anticipated difficult airway Heart block Recent histort of URTI.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To evaluate if combination of low dose rocuronium 0.6 mg/kg IV with magnesium sulphate 30 mg/kg IV and ketamine 1 mg/kg IV provides better intubating conditions compared to high dose rocuronium 0.9 mg/kg IV alone,at 60 seconds.	At 60 seconds after induction.

Secondary Outcome Measures

Name	Time	Method
To compare hemodynamic response mean arterial pressure and heart rate between the two groups	At baseline, after induction, after intubation, 3 minutes and 6 minutes thereafter.

Trial Locations

Locations (1): Amrita Institute of medical sciences
🇮🇳
Ernakulam, KERALA, India
Amrita Institute of medical sciences
🇮🇳Ernakulam, KERALA, India
Rekha Varghese
Principal investigator
9447325249
rekhavarghese@aims.amrita.edu