Evaluation of the Diaphragm Performance During Weaning From Mechanical Ventilation

Recruiting

• Conditions: Mechanical Ventilation Weaning
• Interventions: Diagnostic Test: diaphragm ultrasound monitoring

• Registration Number: NCT06203353
• Lead Sponsor: Mongi Slim Hospital

Brief Summary

Prospective observationnal study, including ICU adult patients with invasive mechanical ventilation for at least 48 hours. Patients are included when performing weaning from mechanical ventilation with pressure support (lowest level of pressure support).

Before separating the patient from the ventilator and performing a T tube spontaneous breathing test, diaphragm ultrasound is performed bilaterally : diaphragm excursion, diaphragm thickening fraction and maximal contraction and relaxation velocities with tissue doppler imaging.

Detailed Description

This observationnal study will include patients during weaning from invasive mechanical ventilation: ventilation in pressure support with the lowest level With normal neurological status: glasgow coma scale \> 13 Requiring no vasopressor support

conventionnal diaphragm parameters: diaphram excursion and thickening fraction will be collected bilaterally with the tissue doppler measures: maximal contraction and relaxation velocities, immediately before a T Tube test.

Patients will be divided into 2 groups according to their weaning from mechanicla ventilation outcome, and diaphragm ultrasound patterns will be compared between the 2 groups in order to evaluate the performance of tissue doppler in predicting weaning outcome.

Study Timeline

• Study Start: 2023-11-01
• Status Verified: 2023-12
• Study First Submitted: 2023-12-28
• Study First Submitted QC: 2024-01-11
• Last Update Submitted: 2024-01-11
• Study First Posted: 2024-01-12
• Last Update Posted: 2024-01-12
• Primary Completion: 2024-11-30
• Study Completion: 2024-12-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Invasive mechanical ventilation for at least 48 hours

Exclusion Criteria

• reintubation for extra respiratory failure (neurologic or hemodynamic)
• Patients with chronic repiratory failure

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
weaning success	diaphragm ultrasound monitoring	Patients extubated with no need to non invasive ventilatry support during 48 hours
weaning failure	diaphragm ultrasound monitoring	patients requiring reintubation or non invasive ventilation within 48 hours after extubation

Primary Outcome Measures

Name	Time	Method
weaning from mechanical ventilation success	Day 2	no need of non invasive ventilation or reintubation

Trial Locations

Locations (1)

Mongi Slim hospital; 🇹🇳 Tunis, Tunisia